Agnogenic myeloid metaplasia in an ovarian steroid cell tumor with virilization - A case report

BACKGROUND: Extramedullary hematopoiesis in patients without hematologic disorders is very rare and has apparently never been described previously in association with an ovarian steroid cell tumor. CASE: An 18-year-old woman was admitted to our clinic due to primary amenorrhea. On examination she had significant facial hirsutism, clitoromegaly and Adam's apple. The serum level of testosterone was elevated. A 7-cm, right ovarian mass was enucleated during laparotomy. Histology revealed a steroid cell tumor with foci of myeloid metaplasia; bony trabecula formation was present. There was no evidence of hematologic or systemic disease. The hormone values became normal 1 month postoperatively. CONCLUSION: This report describes a patient with agnogenic myeloid metaplasia in an ovarian steroid cell tumor with virilization; this association was not previously reported.