Does chemotherapy or radiotherapy affect the postoperative complication in breast cancer patients who underwent immediate breast reconstruction with tissue expander?

被引：14

作者：

Jung, Sung Mi ^{[1
]}

Jeon, Byung-Joon ^{[2
]}

Woo, Jinsun ^{[1
]}

Ryu, Jai Min ^{[1
]}

Lee, Se Kyung ^{[1
]}

Chae, Byung-Joo ^{[1
]}

Yu, Jonghan ^{[1
]}

Kim, Seok Won ^{[1
]}

Nam, Seok Jin ^{[1
]}

Pyon, Jai-Kyong ^{[2
]}

Mun, Goo-Hyun ^{[2
]}

Bang, Sa Ik ^{[2
]}

Lee, Jeong Eon ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Breast Surg,Dept Surg, Irwon Ro 81, Seoul 06351, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Plast Surg, Irwon Ro 81, Seoul 06351, South Korea

来源：

BMC CANCER | 2021年 / 21卷 / 01期

关键词：

Breast neoplasm; Chemotherapy; Adjuvant; Postoperative complications; Radiotherapy; Tissue expansion devices;

D O I：

10.1186/s12885-020-07729-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundImmediate breast reconstruction with tissue expander in breast cancer patients who were expected to receive adjuvant therapy, such as chemotherapy or radiotherapy, has been a topic of debate. Postoperative complications from tissue expander procedures can delay the timing of adjuvant treatment and subsequently increase the probability of recurrence. The purpose of this study was to identify the impact of chemotherapy and radiotherapy on postoperative complications in patients who underwent immediate reconstruction (IR) using tissue expander.MethodsWe conducted a retrospective study of 1081 breast cancer patients who underwent mastectomy and IR using tissue expander insertion between 2012 and 2017 in Samsung Medical Center. The patients were divided into two groups based on complications (complication group vs. no complication group). Complication group was regarded to have surgical removal or conservative treatment based on clinical findings such as infection, capsular contracture, seroma, hematoma, rupture, malposition, tissue viability, or cosmetic problem. The complication group had 59 patients (5.5%) and the no complication group had 1022 patients (94.5%).ResultsIn univariate analysis, adjuvant radiotherapy and adjuvant chemotherapy were significantly associated with postoperative complications. In multivariate analysis, however, only higher pathologic N stage was significantly associated with postoperative complications (p<0.001). Chemotherapy (p=0.775) or radiotherapy (p=0.825) were not risk factors for postoperative complications.ConclusionsIR with tissue expander after mastectomy may be a treatment option even when the patients are expected to receive adjuvant chemotherapy or radiotherapy. These results will aid patients who are concerned about the complications of IR caused by chemotherapy or radiotherapy determine whether or not to have IR.Trial registrationPatients were selected and registered retrospectively, and medical records were evaluated.

引用

页数：10

共 41 条

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