In vitro anticancer activity of AIEgens

被引：11

作者：

Yin, Feng ^{[1
]}

Gu, Bobo ^{[2
,3
]}

Li, Jingxu ^{[1
]}

Panwar, Nishtha ^{[4
]}

Liu, Yong ^{[5
]}

Li, Zigang ^{[1
]}

Yong, Ken-Tye ^{[4
]}

Tang, Ben Zhong ^{[5
]}

机构：

[1] Peking Univ, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen, Key Lab Chem Genom,Shenzhen Grad Sch, Shenzhen 518055, Peoples R China

[2] Shanghai Jiao Tong Univ, Med X Res Inst, 1954 Huashan Rd, Shanghai 200030, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Biomed Engn, 1954 Huashan Rd, Shanghai 200030, Peoples R China

[4] Nanyang Technol Univ, Sch Elect & Elect Engn, 50 Nanyang Ave, Singapore 639798, Singapore

[5] Hong Kong Univ Sci & Technol, Dept Chem, HKUST Jockey Club Inst Adv Study,Div Life Sci,Kow, Inst Mol Funct Mat,Div Biomed Engn,State Key Lab, Clear Water Bay, Hong Kong, Peoples R China

来源：

BIOMATERIALS SCIENCE | 2019年 / 7卷 / 09期

关键词：

AGGREGATION-INDUCED EMISSION; STEM-CELLS; EFFICIENT PHOTOSENSITIZERS; PHOTODYNAMIC THERAPY; QUANTUM DOTS; CANCER; THERANOSTICS; DELIVERY; NANOPARTICLES; NANOMATERIALS;

D O I：

10.1039/c9bm00881k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Fluorogens with aggregation-induced emission (AIE) characteristics (AIEgens) possess unique optical properties, design flexibility, and multi-functional capabilities and have established their niche as smart materials since their discovery in 2001. In recent years, AIEgens have found varied applications in sensing, imaging, and therapy in biomedical research. In this work, we systematically and comprehensively investigate the in vitro anticancer activity of AIEgens. We report the high cytotoxicity of AIEgens against cancer cells, especially against cancer stem cells (CSCs) which show high resistance to existing therapeutic drug regimens. Furthermore, we explore the role of AIEgens as novel image-guided chemotherapy agents that offer a new avenue for efficient cancer treatment.

引用

页码：3855 / 3865

页数：11

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