Sarcoidosis and uveitis

被引:115
作者
Jamilloux, Yvan [1 ]
Kodjilcian, Laurent [2 ]
Broussolle, Christiane [1 ]
Seve, Pascal [1 ]
机构
[1] Univ Lyon 1, Hop Croix Rousse, Dept Internal Med, F-69365 Lyon, France
[2] Univ Lyon 1, Hop Croix Rousse, Dept Ophthalmol, F-69365 Lyon, France
关键词
Sarcoidosis; Uveitis; Ocular sarcoidosis; FDG-PET; Anti-TNF alpha; PERIPHERAL MULTIFOCAL CHORIORETINITIS; 1ST INTERNATIONAL WORKSHOP; PLACEBO-CONTROLLED TRIAL; SALIVARY-GLAND BIOPSY; OCULAR SARCOIDOSIS; CONJUNCTIVAL BIOPSY; CLINICAL CHARACTERISTICS; BRONCHOALVEOLAR LAVAGE; PULMONARY SARCOIDOSIS; INTRAVITREAL IMPLANT;
D O I
10.1016/j.autrev.2014.04.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Uveitis is a frequent (20-50%) and early feature of sarcoidosis. Typical sarcoid uveitis presents with mutton-fat keratic precipitates, iris nodules, and anterior and posterior synechiae. Posterior involvement includes vitreitis, vasculitis, and choroidal lesions. Cystoid macular edema is the most important and sight-threatening consequence. Histologic proof from a biopsy is the gold standard for the diagnosis of ocular sarcoidosis. An international workshop has recently established diagnostic criteria for sarcoidosis uveitis when biopsy is unavailable or negative: these are based on a combination of ophthalmological findings and laboratory tests. The value of recent techniques, such as PET-scan and endoscopic ultrasound-guided, fine-needle aspiration of intrathoracic nodes needs to be assessed in future studies. Corticosteroids are the mainstay treatment for sarcoidosis. Systemic corticosteroids are indicated when uveitis does not respond to topical corticosteroids or when there is bilateral posterior involvement, especially macular edema and occlusive vasculitis. In up to 15% of cases, additional immunosuppression is used, including methotrexate, azathioprine, and mycophenolate mofetil. Infliximab and adalimumab have been recently proposed for the treatment of refractory or sight-threatening systemic sarcoidosis. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:840 / 849
页数:10
相关论文
共 109 条
[1]   Association of peripheral multifocal choroiditis with sarcoidosis:: A study of thirty-seven patients [J].
Abad, S ;
Meyssonier, V ;
Allali, J ;
Gouya, H ;
Giraudet, AL ;
Monnet, D ;
Parc, C ;
Tenenbaum, F ;
Alberini, JL ;
Grabar, S ;
Pesce, F ;
Rollot, F ;
Sicard, D ;
Dhote, R ;
Blanche, P ;
Brézin, AP .
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2004, 51 (06) :974-982
[2]   Efficacy and safety of convex probe EBUS-TBNA in sarcoidosis: A systematic review and meta-analysis [J].
Agarwal, Ritesh ;
Srinivasan, Arjun ;
Aggarwal, Ashutosh N. ;
Gupta, Dheeraj .
RESPIRATORY MEDICINE, 2012, 106 (06) :883-892
[3]   Mutation screening of the CARD15 gene in sarcoidosis [J].
Akahoshi, M. ;
Ishihara, M. ;
Namba, K. ;
Kitaichi, N. ;
Ando, Y. ;
Takenaka, S. ;
Ishida, T. ;
Ohno, S. ;
Mizuki, N. ;
Nakashima, H. ;
Shirakawa, T. .
TISSUE ANTIGENS, 2008, 71 (06) :564-567
[4]   Interferon release assay for the diagnosis of uveitis associated with tuberculosis: a Bayesian evaluation in the absence of a gold standard [J].
Ang, Marcus ;
Wong, Wan Ling ;
Li, Xiang ;
Chee, Soon-Phaik .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2013, 97 (08) :1062-1067
[5]  
Asukata Y, 2009, MOL VIS, V15, P2673
[6]   THE PREDICTIVE VALUE OF SERUM ANGIOTENSIN CONVERTING ENZYME AND LYSOZYME LEVELS IN THE DIAGNOSIS OF OCULAR SARCOIDOSIS [J].
BAARSMA, GS ;
LAHEY, E ;
GLASIUS, E ;
DEVRIES, J ;
KIJLSTRA, A .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1987, 104 (03) :211-217
[7]   EFFICACY AND SAFETY OF INTRAVITREAL BEVACIZUMAB COMPARED WITH INTRAVITREAL AND POSTERIOR SUB-TENON TRIAMCINOLONE ACETONIDE FOR TREATMENT OF UVEITIC CYSTOID MACULAR EDEMA [J].
Bae, Jeong Hun ;
Lee, Christopher Seungkyu ;
Lee, Sung Chul .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2011, 31 (01) :111-118
[8]   Uveitis- a rare disease often associated with systemic diseases and infections- a systematic review of 2619 patients [J].
Barisani-Asenbauer, Talin ;
Maca, Saskia M. ;
Mejdoubi, Lamiss ;
Emminger, Wolfgang ;
Machold, Klaus ;
Auer, Herbert .
ORPHANET JOURNAL OF RARE DISEASES, 2012, 7
[9]  
Baughman RP, 2012, SARCOIDOSIS VASC DIF, V29, P26
[10]   Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement [J].
Baughman, Robert P. ;
Drent, Marjolein ;
Kavuru, Mani ;
Judson, Marc A. ;
Costabel, Ulrich ;
du Bois, Roland ;
Albera, Carlo ;
Brutsche, Martin ;
Davis, Gerald ;
Donohue, James F. ;
Mueller-Quernheim, Joachim ;
Schlenker-Herceg, Rozsa ;
Flavin, Susan ;
Lo, Kim Hung ;
Oemar, Barry ;
Barnathan, Elliot S. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 174 (07) :795-802