Rhodium(III)-Catalyzed C-C Bond Formation of Quinoline N-Oxides at the C-8 Position under Mild Conditions

被引：202

作者：

Jeong, Jisu ^{[1
,2
]}

Patel, Pitambar ^{[1
,2
]}

Hwang, Heejun ^{[1
,2
]}

Chang, Sukbok ^{[1
,2
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

[2] Inst for Basic Sci Korea, Ctr Catalyt Hydrocarbon Functionalizat, Taejon 305701, South Korea

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 17期

关键词：

DIRECT ALKYNYLATION; H ALKYNYLATION; CARBENOID FUNCTIONALIZATION; RH(III)-CATALYZED SYNTHESIS; REGIOSELECTIVE SYNTHESIS; DIRECT ARYLATION; DIAZO-COMPOUNDS; PALLADIUM; ACTIVATION; ARYL;

D O I：

10.1021/ol502173d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Rh(III)-catalyzed C-8 selective direct alkylation and alkynylation of quinoline N-oxides has been developed. The reactions proceeded highly efficiently at room temperature over a broad range of substrates with excellent regioselectivity and functional group tolerance. This development demonstrates the synthetic utility of the N-oxide directing group as a stepping stone for remote C H functionalization of quinolines.

引用

页码：4598 / 4601

页数：4

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