Convenient synthesis of 1a,1b,2,5-tetrahydro-1H-5a-aza-cyclopropa[a]indenes by base promoted cyclodimerization of 1,1-dicyano-2-aryl-3-benzoylcyclopropanes

被引：9

作者：

Han, Ying ^{[1
]}

Tang, Wan-Quan ^{[1
]}

Guo, Ling-Yu ^{[1
]}

Yan, Chao-Guo ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

TETRAHEDRON | 2014年 / 70卷 / 37期

基金：

中国国家自然科学基金;

关键词：

Cyclopropane; Pyridine ylide; Ring-opening reaction; Cyclodimerization; Domino reaction; MGI2-MEDIATED RING EXPANSIONS; DONOR-ACCEPTOR CYCLOPROPANES; ACTIVATED CYCLOPROPANES; STEREOSELECTIVE-SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; 3+2 CYCLOADDITION; EFFICIENT; CONSTRUCTION; DIMERIZATION; METHODOLOGY;

D O I：

10.1016/j.tet.2014.06.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,1-Dicyano-2-aryl-3-benzoylcyclopropanes in acetonitrile in the presence of triethylamine underwent cyclodimerization reaction to afford the novel polyfunctionalized 1a,1b,2,5-tetrahydro-1H-5a-aza-cyclopropa[a]indenes in moderate yields. These polycyclic compounds can be more conveniently synthesized by the one-pot domino reaction of N-phenacylpyridinium bromides with arylidene malononitriles. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：6663 / 6668

页数：6

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