Expression of a C terminally truncated form of pertussis toxin S1 subunit effectively induces protection against pertussis toxin following DNA-based immunization

被引：9

作者：

Kamachi, K ^{[1
]}

Arakawa, Y ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Bacterial Pathogenesis & Infect Control, Tokyo 2080011, Japan

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 07期

关键词：

D O I：

10.1128/IAI.72.7.4293-4296.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Four plasmids encoding different C terminally and N terminally truncated pertussis toxin S1 subunits of Bordetella pertussis were constructed and tested for inducibility of protection against pertussis toxin in mice after DNA-based immunization. The region encoding an N-terminal 180-amino-acid fragment of the S1 subunit had the most potent ability to induce protective immunity.

引用

页码：4293 / 4296

页数：4

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