Analysis of the response of human keratinocytes to Malassezia globosa and restricta strains

被引：44

作者：

Donnarumma, Giovanna ^{[1
]}

Perfetto, Brunella ^{[1
]}

Paoletti, Iole ^{[1
]}

Oliviero, Giovanni ^{[1
]}

Clavaud, Cecile ^{[2
]}

Del Bufalo, Aurelia ^{[2
]}

Gueniche, Audrey ^{[2
]}

Jourdain, Roland ^{[2
]}

Tufano, Maria Antonietta ^{[1
]}

Breton, Lionel ^{[2
]}

机构：

[1] Univ Naples 2, Microbiol Sect, Dept Expt Med, I-80138 Naples, Italy

[2] LOreal Res & Innovat, F-93600 Aulnay Sous Bois, France

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2014年 / 306卷 / 08期

关键词：

Malassezia spp; Keratinocytes; Dandruff; TLRs; EXPRESSION;

D O I：

10.1007/s00403-014-1479-1

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Malassezia spp. are saprophyte yeasts involved in skin diseases with different degrees of severity. The aim of our study was to analyze the response of human epidermal keratinocytes to Malassezia globosa and restricta strains evaluating the host defence mechanisms induced by Malassezia spp. colonization. Our results showed a different modulation of the inflammatory and immunomodulatory cytokine pathways obtained with the different strains of Malassezia tested. In addition, this expression is altered by blocking the TLR2 receptor. In comparison with M. furfur, M. globosa and restricta displayed an unexpected and striking cytotoxicity on keratinocytes. The differences observed could be related to the different modalities of interaction between keratinocytes and Malassezia strains, but also to their growth condition. Taken together, these results indicate that M. globosa or M. restricta colonization exert a different control on the cytokine inflammatory response activated in the human keratinocyte in which TLR2 might be involved. M. globosa and M. restricta may play a synergistic role in the exacerbation of skin diseases in which both are found.

引用

页码：763 / 768

页数：6

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