New Biologically Active Hydrogen Sulfide Donors

被引：62

作者：

Roger, Thomas ^{[1
]}

Raynaud, Francoise ^{[1
]}

Bouillaud, Frederic ^{[2
]}

Ransy, Celine ^{[2
]}

Simonet, Serge ^{[3
]}

Crespo, Christine ^{[3
]}

Bourguignon, Marie-Pierre ^{[3
]}

Villeneuve, Nicole ^{[3
]}

Vilaine, Jean-Paul ^{[3
]}

Artaud, Isabelle ^{[1
]}

Galardon, Erwan ^{[1
]}

机构：

[1] Univ Paris 05, PRES Sorbonne Paris Cite, CNRS, LCBPT,UMR 8601, F-75006 Paris, France

[2] Univ Paris 05, PRES Sorbonne Paris Cite, CNRS UMR 8104, Inst Cochin,Inserm U1016, F-75014 Paris, France

[3] Inst Rech SERVIER, Unite Cardiovasc, F-92150 Suresnes, France

来源：

CHEMBIOCHEM | 2013年 / 14卷 / 17期

关键词：

biological activity; dithioperoxyanhydrides; hydrogen sulfide; oxidoreductases; SQR; vasorelaxation; LYSINE ACETYLATION; FLUORESCENT-PROBES; H2S; SULFUR; SULFHYDRATION; VASOACTIVITY; METABOLISM; OXIDATION; BIOLOGY; TISSUES;

D O I：

10.1002/cbic.201300552

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Generous donors: The dithioperoxyanhydrides (CH3COS) 2, (PhCOS)2, CH3COSSCO2Me and PhCOSSCO2Me act as thiol-activated hydrogen sulfide donors in aqueous buffer solution. The most efficient donor (CH3COS)2 can induce a biological response in cells, and advantageously replace hydrogen sulfide in ex vivo vascular studies. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2268 / 2271

页数：4

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