Smad7:: Licensed to kill β-catenin

被引：14
作者：
Millar, Sarah E.
机构：
[1] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Dermatol, Sch Med, M8D Stellar Chance Labs, Philadelphia, PA 19104 USA
来源：
DEVELOPMENTAL CELL | 2006年 / 11卷 / 03期
关键词：
D O I：
10.1016/j.devcel.2006.08.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Elevated levels of inhibitory Smad7 are detected in several pathologic skin conditions; however the functional consequences of this expression have been unclear. A recent study shows that Smad7 overexpression in transgenic mouse epidermis at levels comparable to those seen in pathologic states is insufficient to block TGF beta or BMP signaling, but instead produces striking phenotypes due to degradation of beta-catenin through a novel mechanism involving Smad7 and Smurf2.
引用
收藏
页码：274 / 276
页数：3
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