A review on the role of carnitine in the management of tamoxifen side effects in treated women with breast cancer

被引：12
作者：
El-Ashmawy, Nahla E. [1 ]
Khalil, Rania M. [2 ]
机构：
[1] Tanta Univ, Dept Biochem, Fac Pharm, Tanta, Egypt
[2] Delta Univ, Dept Biochem, Fac Pharm, Gamasah, Egypt
来源：
TUMOR BIOLOGY | 2014年 / 35卷 / 04期
关键词：
Breast cancer; Cancer prognosis; L-carnitine; Resistance; Side effects; Tamoxifen; ACETYL-L-CARNITINE; RANDOMIZED DOUBLE-BLIND; PROPIONYL-L-CARNITINE; FATTY-ACID SYNTHASE; GROWTH-FACTOR-I; POSTMENOPAUSAL WOMEN; OXIDATIVE STRESS; DEPRESSED MOOD; HUMAN CORNEAL; FATIGUE;
D O I：
10.1007/s13277-013-1477-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
l-carnitine is an antioxidant and is found to be a protective agent against many diseases including cancer. This review illustrates the possible role of l-carnitine as an add-on therapy to breast cancer patients maintained on tamoxifen. The objectives of carnitine treatment are diverse: improving tamoxifen-related side effects, offering better cancer prognosis by reducing the risk of developing cancer recurrence or metastasis, and modulating the growth factors which may be, in part, a prospective illustration to overcome tamoxifen resistance. So, it could be recommended to supplement l-carnitine to breast cancer patients starting tamoxifen treatment.
引用
收藏
页码：2845 / 2855
页数：11
相关论文
共 50 条
  • [31] Tamoxifen in women with breast cancer and mammographic density
    Meggiorini, M. L.
    Labi, L.
    Vestri, A. R.
    Porfiri, L. M.
    Savelli, S.
    De Felice, C.
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2008, 29 (06) : 598 - 601
  • [32] Tamoxifen and fenretinide in women with metastatic breast cancer
    Zujewski, J
    Pai, L
    Wakefield, L
    Giusti, R
    Dorr, FA
    Flanders, C
    Caruso, R
    Kaiser, M
    Goodman, L
    Merino, M
    Gossard, M
    Noone, MA
    Denicoff, A
    Venzon, D
    Cowan, KH
    O'Shaughnessy, JA
    BREAST CANCER RESEARCH AND TREATMENT, 1999, 57 (03) : 277 - 283
  • [33] Tamoxifen and fenretinide in women with metastatic breast cancer
    J. Zujewski
    L. Pai
    L. Wakefield
    R. Giusti
    F.A. Dorr
    C. Flanders
    R. Caruso
    M. Kaiser
    L. Goodman
    M. Merino
    M. Gossard
    M.A. Noone
    A. Denicoff
    D. Venzon
    K.H. Cowan
    J.A. O'Shaughnessy
    Breast Cancer Research and Treatment, 1999, 57 : 277 - 283
  • [34] Bone metastasis in breast cancer is treated by high-dose tamoxifen
    Stathopoulos, George P.
    Trafalis, Dimitrios
    Kaparelou, Maria
    JOURNAL OF BUON, 2016, 21 (04): : 1013 - 1015
  • [35] Tamoxifen and Sulphoraphane for the breast cancer management: A synergistic nanomedicine approach
    Mangla, Bharti
    Neupane, Yub Raj
    Singh, Archu
    Kohli, Kanchan
    MEDICAL HYPOTHESES, 2019, 132
  • [36] The role of interleukin 8 and matrix metalloproteinases 2 and 9 in breast cancer treated with tamoxifen
    Milovanovic, Jelena
    Todorovic-Rakovic, Natasa
    Abu Rabi, Zaki
    JOURNAL OF BUON, 2017, 22 (03): : 628 - 637
  • [37] An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management
    Khallouki, Farid
    Hajji, Lhoussain
    Saber, Somayya
    Bouddine, Toufik
    Edderkaoui, Mouad
    Bourhia, Mohammed
    Mir, Nora
    Lim, Adrian
    El Midaoui, Adil
    Giesy, John P.
    Aboul-Soud, Mourad A. M.
    Silvente-Poirot, Sandrine
    Poirot, Marc
    JOURNAL OF PERSONALIZED MEDICINE, 2023, 13 (05):
  • [38] Polymorphism of the CYP2D6 gene in women with breast cancer treated with tamoxifen
    de Vasconcelos-Valenca, R. J.
    Melo, M. A.
    Lima, E. M.
    de Sousa, G. V.
    Nazario, A. C.
    da Silva, B. B.
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2016, 37 (05) : 700 - 702
  • [39] Indication of hysteroscopy in tamoxifen treated breast cancer patients
    Taponeco, F
    Curcio, C
    Fasciani, A
    Giuntini, A
    Artini, PG
    Fornaciari, G
    Petraglia, F
    Genazzani, AR
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2002, 21 (01) : 37 - 43
  • [40] Retrospective review of male breast cancer patients: analysis of tamoxifen-related side-effects
    Pemmaraju, N.
    Munsell, M. F.
    Hortobagyi, G. N.
    Giordano, S. H.
    ANNALS OF ONCOLOGY, 2012, 23 (06) : 1471 - +
12345