A review on the role of carnitine in the management of tamoxifen side effects in treated women with breast cancer

被引：12
作者：
El-Ashmawy, Nahla E. [1 ]
Khalil, Rania M. [2 ]
机构：
[1] Tanta Univ, Dept Biochem, Fac Pharm, Tanta, Egypt
[2] Delta Univ, Dept Biochem, Fac Pharm, Gamasah, Egypt
来源：
TUMOR BIOLOGY | 2014年 / 35卷 / 04期
关键词：
Breast cancer; Cancer prognosis; L-carnitine; Resistance; Side effects; Tamoxifen; ACETYL-L-CARNITINE; RANDOMIZED DOUBLE-BLIND; PROPIONYL-L-CARNITINE; FATTY-ACID SYNTHASE; GROWTH-FACTOR-I; POSTMENOPAUSAL WOMEN; OXIDATIVE STRESS; DEPRESSED MOOD; HUMAN CORNEAL; FATIGUE;
D O I：
10.1007/s13277-013-1477-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
l-carnitine is an antioxidant and is found to be a protective agent against many diseases including cancer. This review illustrates the possible role of l-carnitine as an add-on therapy to breast cancer patients maintained on tamoxifen. The objectives of carnitine treatment are diverse: improving tamoxifen-related side effects, offering better cancer prognosis by reducing the risk of developing cancer recurrence or metastasis, and modulating the growth factors which may be, in part, a prospective illustration to overcome tamoxifen resistance. So, it could be recommended to supplement l-carnitine to breast cancer patients starting tamoxifen treatment.
引用
收藏
页码：2845 / 2855
页数：11
相关论文
共 106 条
[71]   Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer [J].
Nahta, Rita ;
Yu, Dihua ;
Hung, Mien-Chie ;
Hortobagyi, Gabriel N. ;
Esteva, Francisco J. .
NATURE CLINICAL PRACTICE ONCOLOGY, 2006, 3 (05) :269-280
[72]  
Naini AE, 2012, SAUDI J KIDNEY DIS T, V23, P484
[73]   Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase [J].
Nazarewicz, Rafal R. ;
Zenebe, Woineshet J. ;
Parihar, Arti ;
Larson, Sarah K. ;
Alidema, Enver ;
Choi, Jiho ;
Ghafourifar, Pedram .
CANCER RESEARCH, 2007, 67 (03) :1282-1290
[74]   Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and risk of benign prostate hyperplasia in the prostate cancer prevention trial [J].
Neuhouser, Marian L. ;
Schenk, Jeannette ;
Song, Yoon Ju ;
Tangen, Catherine M. ;
Goodman, Phyllis J. ;
Pollak, Michael ;
Penson, David F. ;
Thompson, Ian M. ;
Kristal, Alan R. .
PROSTATE, 2008, 68 (13) :1477-1486
[75]   Prothrombin Time and Partial Thromboplastin Time Assay Considerations [J].
Ng, Valerie L. .
CLINICS IN LABORATORY MEDICINE, 2009, 29 (02) :253-+
[76]   Estrogen receptor genotypes, menopausal status, and the lipid effects of tamoxifen [J].
Ntukidem, N. I. ;
Nguyen, A. T. ;
Stearns, V. ;
Rehman, M. ;
Schott, A. ;
Skaar, T. ;
Jin, Y. ;
Blanche, P. ;
Li, L. ;
Lemler, S. ;
Hayden, J. ;
Krauss, R. M. ;
Desta, Z. ;
Flockhart, D. A. ;
Hayes, D. F. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 (05) :702-710
[77]   Metabolic Agents that Enhance ATP can Improve Cognitive Functioning: A Review of the Evidence for Glucose, Oxygen, Pyruvate, Creatine, and L-Carnitine [J].
Owen, Lauren ;
Sunram-Lea, Sandra I. .
NUTRIENTS, 2011, 3 (08) :735-755
[78]   A double-blind placebo-controlled study to evaluate endometrial safety and gynaecological symptoms in women treated for up to 5 years with tamoxifen or placebo - A substudy for IBIS I Breast Cancer Prevention Trial [J].
Palva, Tiina ;
Ranta, Hannu ;
Koivisto, Anna-Maija ;
Pylkkanen, Liisa ;
Cuzick, Jack ;
Holli, Kaija .
EUROPEAN JOURNAL OF CANCER, 2013, 49 (01) :45-51
[79]   Alternative Medical Interventions Used in the Treatment and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia [J].
Porter, Nicole S. ;
Jason, Leonard A. ;
Boulton, Aaron ;
Bothne, Nancy ;
Coleman, Blair .
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2010, 16 (03) :235-249
[80]   Cardiovascular health and aromatase inhibitors [J].
Pritchard, Kathleen I. ;
Abramson, Beth L. .
DRUGS, 2006, 66 (13) :1727-1740
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