A review on the role of carnitine in the management of tamoxifen side effects in treated women with breast cancer

被引：12
作者：
El-Ashmawy, Nahla E. [1 ]
Khalil, Rania M. [2 ]
机构：
[1] Tanta Univ, Dept Biochem, Fac Pharm, Tanta, Egypt
[2] Delta Univ, Dept Biochem, Fac Pharm, Gamasah, Egypt
来源：
TUMOR BIOLOGY | 2014年 / 35卷 / 04期
关键词：
Breast cancer; Cancer prognosis; L-carnitine; Resistance; Side effects; Tamoxifen; ACETYL-L-CARNITINE; RANDOMIZED DOUBLE-BLIND; PROPIONYL-L-CARNITINE; FATTY-ACID SYNTHASE; GROWTH-FACTOR-I; POSTMENOPAUSAL WOMEN; OXIDATIVE STRESS; DEPRESSED MOOD; HUMAN CORNEAL; FATIGUE;
D O I：
10.1007/s13277-013-1477-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
l-carnitine is an antioxidant and is found to be a protective agent against many diseases including cancer. This review illustrates the possible role of l-carnitine as an add-on therapy to breast cancer patients maintained on tamoxifen. The objectives of carnitine treatment are diverse: improving tamoxifen-related side effects, offering better cancer prognosis by reducing the risk of developing cancer recurrence or metastasis, and modulating the growth factors which may be, in part, a prospective illustration to overcome tamoxifen resistance. So, it could be recommended to supplement l-carnitine to breast cancer patients starting tamoxifen treatment.
引用
收藏
页码：2845 / 2855
页数：11
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