Aneugenic effect of ionizing radiation in mammalian and human somatic cells

被引：3
|
作者：
Vasilyev, S. A. [1 ]
Timoshevsky, V. A. [1 ]
Lebedev, I. N. [1 ]
机构：
[1] Russian Acad Med Sci, Tomsk Sci Ctr, Inst Med Genet, Tomsk 634050, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2009年 / 45卷 / 12期
基金：
俄罗斯基础研究基金会;
关键词：
IN-SITU HYBRIDIZATION; BLOCKED HUMAN-LYMPHOCYTES; MICRONUCLEUS ASSAY; X-RAYS; INSITU HYBRIDIZATION; ANEUPLOIDY INDUCTION; GENOMIC INSTABILITY; NONDISJUNCTION; VITRO; IDENTIFICATION;
D O I：
10.1134/S1022795409120011
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aneuploidy is among the most serious impairments of hereditary material in somatic and germline cells of living organisms. Chromosome loss or the appearance of an extra homolog in the chromosome set can result in either cell death or the development of various neoplasms with high probability of malignancy. It was traditionally believed that ionizing radiation produces primarily a clastogenic effect. However, there is apparently an aneugenic component of radiation, with mechanism different from that of structural chromosome damage. The present review focuses on the evidence for the existence of the aneugenic effect of ionizing radiation in mammalian and human somatic cells.
引用
收藏
页码：1403 / 1412
页数：10
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