Abnormally increased vocal responses to pitch feedback perturbations in patients with cerebellar degeneration

被引：29

作者：

Houde, John F. ^{[1
]}

Gill, Jeevit S. ^{[1
]}

Agnew, Zarinah ^{[1
]}

Kothare, Hardik ^{[2
,3
]}

Hickok, Gregory ^{[4
,5
]}

Parrell, Benjamin ^{[6
]}

Ivry, Richard B. ^{[7
]}

Nagarajan, Srikantan S. ^{[1
,8
]}

机构：

[1] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Program Bioengn, San Francisco, CA 94143 USA

[3] Univ Calif Berkeley, San Francisco, CA 94143 USA

[4] Univ Calif Irvine, Dept Cognit Sci, Irvine, CA 92697 USA

[5] Univ Calif Irvine, Dept Language Sci, Irvine, CA 92697 USA

[6] Univ Wisconsin, Dept Commun Sci & Disorders, Madison, WI 53706 USA

[7] Univ Calif Berkeley, Dept Psychol, 3210 Tolman Hall, Berkeley, CA 94720 USA

[8] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

来源：

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA | 2019年 / 145卷 / 05期

关键词：

COMPUTATIONAL NEUROANATOMY; AUDITORY-FEEDBACK; SPEECH PRODUCTION; INTERNAL-MODELS; MOTOR CONTROL; COMPENSATION; INVOLVEMENT; MECHANISMS;

D O I：

10.1121/1.5100910

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Cerebellar degeneration ( CD) has deleterious effects on speech motor behavior. Recently, a dissociation between feedback and feedforward control of speaking was observed in CD: Whereas CD patients exhibited reduced adaptation across trials to consistent formant feedback alterations, they showed enhanced within-trial compensation for unpredictable formant feedback perturbations. In this study, it was found that CD patients exhibit abnormally increased within-trial vocal compensation responses to unpredictable pitch feedback perturbations. Taken together with recent findings, the results indicate that CD is associated with a general hypersensitivity to auditory feedback during speaking. (C) 2019 Acoustical Society of America

引用

页码：EL372 / EL378

页数：7

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