Promoting axonal rewiring to improve outcome after stroke

被引:183
作者
Benowitz, Larry I. [1 ]
Carmichael, S. Thomas [2 ]
机构
[1] Harvard Univ, Sch Med, Boston, MA 02115 USA
[2] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA
关键词
MYELIN-ASSOCIATED GLYCOPROTEIN; CEREBRAL-ARTERY OCCLUSION; INDUCED MOVEMENT THERAPY; FIBROBLAST-GROWTH-FACTOR; FUNCTIONAL RECOVERY; SPINAL-CORD; GENE-EXPRESSION; MOTOR FUNCTION; IN-VIVO; NEOCORTICAL INFARCTION;
D O I
10.1016/j.nbd.2009.11.009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A limited amount of functional recovery commonly occurs in the weeks and months after stroke, and a number of studies show that such recovery is associated with changes in the brain's functional organization. Measures that augment this reorganization in a safe and effective way may therefore help improve outcome in stroke patients. Here we review some of the evidence for functional and anatomical reorganization under normal physiological conditions, along with strategies that augment these processes and improve outcome after brain injury in animal models. These strategies include counteracting inhibitors of axon growth associated with myelin, activating neurons' intrinsic growth state, enhancing physiological activity, and having behavioral therapy. These approaches represent a marked departure from the recent focus on neuroprotection and may provide a more effective way to improve outcome after stroke. (c) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:259 / 266
页数:8
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