Electrooxidative Iridium-Catalyzed Regioselective Annulation of Benzoic Acids with Internal Alkynes

被引：40

作者：

Yang, Qi-Liang ^{[1
]}

Jia, Hong-Wei ^{[1
]}

Liu, Ying ^{[1
]}

Xing, Yi-Kang ^{[2
]}

Ma, Rui-Cong ^{[1
]}

Wang, Man-Man ^{[1
]}

Qu, Gui-Rong ^{[1
]}

Mei, Tian-Sheng ^{[2
]}

Guo, Hai-Ming ^{[1
]}

机构：

[1] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Sch Chem & Chem Engn,Minist Educ, Henan Key Lab Organ Funct Mol & Drug Innovat,Key, Xinxiang 453007, Henan, Peoples R China

[2] Chinese Acad Sci, Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,State Key Lab Organometa, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 04期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

C-H ACTIVATION; NATURAL-PRODUCTS; BOND; ISOCOUMARINS; EFFICIENT; ARENES; AMIDES;

D O I：

10.1021/acs.orglett.0c04168

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Electrochemically driven, Cp*Ir(III)-catalyzed regioselective annulative couplings of benzoic acids with alkynes have been established herein. The combination of iridium catalyst and electricity not only circumvents the need for stoichiometric amount of chemical oxidant, but also ensures broad reaction compatibility with a wide array of sterically and electronically diverse substrates. This electrochemical approach represents a sustainable strategy as an ideal alternative and supplement to the oxidative annulations methodology to be engaged in the synthesis of isocoumarin derivatives.

引用

页码：1209 / 1215

页数：7

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