Mini Review Immunological Consequences of Immunization With COVID-19 mRNA Vaccines: Preliminary Results

被引：46

作者：

Lombardi, Andrea ^{[1
,2
]}

Bozzi, Giorgio ^{[1
]}

Ungaro, Riccardo ^{[1
]}

Villa, Simone ^{[3
]}

Castelli, Valeria ^{[1
]}

Mangioni, Davide ^{[1
]}

Muscatello, Antonio ^{[1
]}

Gori, Andrea ^{[1
,2
,3
]}

Bandera, Alessandra ^{[1
,2
,3
]}

机构：

[1] Fdn Ist Ricovero & Cura Carattere Sci IRCCS Ca Gr, Infect Dis Unit, Milan, Italy

[2] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy

[3] Univ Milan, Ctr Multidisciplinary Res Hlth Sci MACH, Milan, Italy

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

COVID-19; SARS-CoV-2; RNA vaccine; CTL; antibodies; neutralization test;

D O I：

10.3389/fimmu.2021.657711

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: BNT162b2 and mRNA-1273 are the two recently approved mRNA-based vaccines against COVID-19 which has shown excellent safety and efficacy. Preliminary data about specific and neutralizing antibodies is available covering the first 100 days after vaccination. Methods: We reviewed all the publications regarding the immunologic consequences of BNT162b2 and mRNA-1273 vaccination. A summary of specific antibodies concentration and neutralizing antibodies titers elicited by each vaccine is provided. Results: BNT162b2 and mRNA-1273 displayed a reassuring safety and efficacy profile, with the latter above 94%. They can elicit specific antibodies titers and neutralizing antibodies concentrations that are far superior from those observed among COVID-19 human convalescent serum, across a wide span of age, for at least 100 days after vaccination. Moreover, the vaccine-induced T cellular response is oriented toward a T(H)1 response and no evidence of vaccine-enhanced disease have been reported. Discussion: BNT162b2 and mRNA-1273 can elicit specific antibodies titers and neutralizing antibodies concentrations above those observed among COVID-19 human convalescent serum in the first 100 days after vaccination. Data about vaccine efficacy in those with previous COVID-19 or immunocompromised is still limited.

引用

页数：11

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