Liver Regeneration after Partial Hepatectomy Critical Analysis of Mechanistic Dilemmas

被引:545
作者
Michalopoulos, George K. [1 ]
机构
[1] Univ Pittsburgh, Dept Pathol, Sch Med, Pittsburgh, PA 15261 USA
关键词
HEPATOCYTE GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; ACTIVATED PROTEIN-KINASE; GAMMA-AMINOBUTYRIC-ACID; INTEGRIN-LINKED KINASE; FACTOR HEPATOPOIETIN-A; FACTOR-KAPPA-B; RAT-LIVER; DNA-SYNTHESIS; EXTRACELLULAR-MATRIX;
D O I
10.2353/ajpath.2010.090675
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Liver regeneration after partial hepatectomy is one of the most studied models of cell, organ, and tissue regeneration. The complexity of the signaling pathways initiating and terminating this process have provided paradigms for regenerative medicine. Many aspects of the signaling mechanisms involved in hepatic regeneration are under active investigation. The purpose of this review is to focus on the areas still not well understood. The review also aims to provide insights into the ways by which current concepts of liver regeneration can provide understanding regarding malfunction of the regenerative process in liver diseases, such as acute liver failure. (Am J Pathol 2010, 176:2-13; DOI: 10.2353/ajpath.2010.090675)
引用
收藏
页码:2 / 13
页数:12
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