Liver Regeneration after Partial Hepatectomy Critical Analysis of Mechanistic Dilemmas

被引：556

作者：

Michalopoulos, George K. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Pathol, Sch Med, Pittsburgh, PA 15261 USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2010年 / 176卷 / 01期

关键词：

HEPATOCYTE GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; ACTIVATED PROTEIN-KINASE; GAMMA-AMINOBUTYRIC-ACID; INTEGRIN-LINKED KINASE; FACTOR HEPATOPOIETIN-A; FACTOR-KAPPA-B; RAT-LIVER; DNA-SYNTHESIS; EXTRACELLULAR-MATRIX;

D O I：

10.2353/ajpath.2010.090675

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Liver regeneration after partial hepatectomy is one of the most studied models of cell, organ, and tissue regeneration. The complexity of the signaling pathways initiating and terminating this process have provided paradigms for regenerative medicine. Many aspects of the signaling mechanisms involved in hepatic regeneration are under active investigation. The purpose of this review is to focus on the areas still not well understood. The review also aims to provide insights into the ways by which current concepts of liver regeneration can provide understanding regarding malfunction of the regenerative process in liver diseases, such as acute liver failure. (Am J Pathol 2010, 176:2-13; DOI: 10.2353/ajpath.2010.090675)

引用

页码：2 / 13

页数：12

共 127 条

[1] ANTIBODIES TO TUMOR-NECROSIS-FACTOR-ALPHA INHIBIT LIVER-REGENERATION AFTER PARTIAL-HEPATECTOMY [J].

AKERMAN, P ;

COTE, P ;

YANG, SQ ;

MCCLAIN, C ;

NELSON, S ;

BAGBY, GJ ;

DIEHL, AM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (04) :G579-G585

[2] Enhanced Liver Regeneration Following Changes Induced by Hepatocyte-Specific Genetic Ablation of Integrin-Linked Kinase [J].

Apte, Udayan ;

Gkretsi, Vasiliki ;

Bowen, William C. ;

Mars, Wendy M. ;

Luo, Jian-Hua ;

Donthamsetty, Shashikiran ;

Orr, Ann ;

Monga, Satdarshan P. S. ;

Wu, Chuanyue ;

Michalopoulos, George K. .

HEPATOLOGY, 2009, 50 (03) :844-851

[3] Amphiregulin:: An early trigger of liver regeneration in mice [J].

Berasain, C ;

García-Trevijano, ER ;

Castillo, J ;

Erroba, E ;

Lee, DC ;

Prieto, J ;

Avila, MA .

GASTROENTEROLOGY, 2005, 128 (02) :424-432

[4] Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium [J].

Block, GD ;

Locker, J ;

Bowen, WC ;

Petersen, BE ;

Katyal, S ;

Strom, SC ;

Riley, T ;

Howard, TA ;

Michalopoulos, GK .

JOURNAL OF CELL BIOLOGY, 1996, 132 (06) :1133-1149

[5] Met provides essential signals for liver regeneration [J].

Borowiak, M ;

Garratt, AN ;

Wüstefeld, T ;

Strehle, M ;

Trautwein, C ;

Birchmeier, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) :10608-10613

[6] TRANSFORMING GROWTH FACTOR-BETA MESSENGER-RNA INCREASES DURING LIVER-REGENERATION - A POSSIBLE PARACRINE MECHANISM OF GROWTH-REGULATION [J].

BRAUN, L ;

MEAD, JE ;

PANZICA, M ;

MIKUMO, R ;

BELL, GI ;

FAUSTO, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1539-1543

[7] Adrenergic stimulation of hepatocyte growth factor expression [J].

Broten, J ;

Michalopoulos, G ;

Petersen, B ;

Cruise, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 262 (01) :76-79

[8]

Bucher N L, 1977, Adv Enzyme Regul, V16, P205, DOI 10.1016/0065-2571(78)90074-2

[9]

BUCHER NLR, 1978, CIBA F S, V55, P95

[10] Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma [J].

Campbell, JS ;

Hughes, SD ;

Gilbertson, DG ;

Palmer, TE ;

Holdren, MS ;

Haran, AC ;

Odell, MM ;

Bauer, RL ;

Ren, HP ;

Haugen, HS ;

Yeh, MM ;

Fausto, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (09) :3389-3394

← 1 2 3 4 5 6 7 8 9 10 →