Severe bronchial asthma patient care organization in various regions of the Russian Federation. From endotypes and phenotypes of bronchial asthma to personalized choice of therapy

被引:2
作者
Avdeev, S. N. [1 ]
Volkova, O. A. [2 ]
Demko, I., V [3 ]
Ignatova, G. L. [4 ]
Leshchenko, I., V [5 ]
Kanukova, N. A. [6 ]
Kudelya, L. M. [7 ]
Nevzorova, V. A. [8 ]
Nedashkovskaya, N. G. [9 ]
Ukhanova, O. P. [10 ]
Shulzhenko, L., V [11 ]
Fassakhov, R. S. [12 ]
机构
[1] Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow, Russia
[2] City Clin Hosp 6, Izhevsk, Russia
[3] Voyno Yasenetsky Krasnoyarsk State Med Univ, Krasnoyarsk, Russia
[4] South Ural State Med Univ, Chelyabinsk, Russia
[5] Ural State Med Univ, Ekaterinburg, Russia
[6] Stavropol Reg Clin Consultat & Diagnost Ctr, Stavropol, Russia
[7] Novosibirsk State Med Univ, Novosibirsk, Russia
[8] Pacific State Med Univ, Vladivostok, Russia
[9] Reg Clin Hosp 2, Rostov Na Donu, Russia
[10] Stavropol State Med Univ, Stavropol, Russia
[11] Kuban State Med Univ, Krasnodar, Russia
[12] Kazan Volga Fed Univ, Kazan, Russia
关键词
severe bronchial asthma; endotype; phenotype; T2-bronchial asthma; biological therapy of bronchial asthma; omalizumab; mepolizumab; resilizumab; dupilumab; benilizumab; INFLAMMATION;
D O I
10.26442/00403660.2020.02.000555
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The meeting of the Expert board was held in Moscow on June 24, 2019, at which the following issues were considered: the applicability of a new terminology characterizing asthma endotypes and phenotypes in real clinical practice, the effect of phenotypes and biomarkers in patients with bronchial asthma on the choice of biological drug, as well as the optimal clinical profiles of patients for whom dupilumab is most effective, taking into account the data of the III phase clinical trials, regional features of medical care and changes in updated international clinical guidelines for the diagnosis and treatment of asthma. The Expert board included members of leading Russian scientific and educational medical institutions: S.N. Avdeev, corresponding member of the Russian Academy of Sciences, prof., MD; O.A. Volkova, Ph.D.; I.V. Demko, prof., MD; G.L. Ignatova, prof., MD; I.V. Leshchenko, prof., MD; Kanukova N.A.; Kudelya L.M., prof., MD; V.A. Nevzorova, prof., MD; N.G. Nedashkovskaya; O.P. Ukhanova, prof., MD; L.V. Shulzhenko, prof., MD; R.S. Fassakhov, prof., MD.
引用
收藏
页码:119 / 123
页数:5
相关论文
共 16 条
[1]   Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials [J].
Bachert, Claus ;
Han, Joseph K. ;
Desrosiers, Martin ;
Hellings, Peter W. ;
Amin, Nikhil ;
Lee, Stella E. ;
Mullol, Joaquim ;
Greos, Leon S. ;
Bosso, John V. ;
Laidlaw, Tanya M. ;
Cervin, Anders U. ;
Maspero, Jorge F. ;
Hopkins, Claire ;
Olze, Heidi ;
Canonica, G. Walter ;
Paggiaro, Pierluigi ;
Cho, Seong H. ;
Fokkens, Wytske J. ;
Fujieda, Shigeharu ;
Zhang, Mei ;
Lu, Xin ;
Fan, Chunpeng ;
Draikiwicz, Steven ;
Kamat, Siddhesh A. ;
Khan, Asif ;
Pirozzi, Gianluca ;
Patel, Naimish ;
Graham, Neil M. H. ;
Ruddy, Marcella ;
Staudinger, Heribert ;
Weinreich, David ;
Stahl, Neil ;
Yancopoulos, George D. ;
Mannent, Leda P. .
LANCET, 2019, 394 (10209) :1638-1650
[2]   Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma [J].
Castro, M. ;
Corren, J. ;
Pavord, I. D. ;
Maspero, J. ;
Wenzel, S. ;
Rabe, K. F. ;
Busse, W. W. ;
Ford, L. ;
Sher, L. ;
FitzGerald, J. M. ;
Katelaris, C. ;
Tohda, Y. ;
Zhang, B. ;
Staudinger, H. ;
Pirozzi, G. ;
Amin, N. ;
Ruddy, M. ;
Akinlade, B. ;
Khan, A. ;
Chao, J. ;
Martincova, R. ;
Graham, N. M. H. ;
Hamilton, J. D. ;
Swanson, B. N. ;
Stahl, N. ;
Yancopoulos, G. D. ;
Teper, A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (26) :2486-2496
[3]   Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation [J].
Chuchalin, Alexander G. ;
Khaltaev, Nikolai ;
Antonov, Nikolay S. ;
Galkin, Dmitry V. ;
Manakov, Leonid G. ;
Antonini, Paola ;
Murphy, Michael ;
Solodovnikov, Alexander G. ;
Bousquet, Jean ;
Pereira, Marcelo H. S. ;
Demko, Irina V. .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2014, 9 :963-974
[4]   International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma [J].
Chung, Kian Fan ;
Wenzel, Sally E. ;
Brozek, Jan L. ;
Bush, Andrew ;
Castro, Mario ;
Sterk, Peter J. ;
Adcock, Ian M. ;
Bateman, Eric D. ;
Bel, Elisabeth H. ;
Bleecker, Eugene R. ;
Boulet, Louis-Philippe ;
Brightling, Christopher ;
Chanez, Pascal ;
Dahlen, Sven-Erik ;
Djukanovic, Ratko ;
Frey, Urs ;
Gaga, Mina ;
Gibson, Peter ;
Hamid, Qutayba ;
Jajour, Nizar N. ;
Mauad, Thais ;
Sorkness, Ronald L. ;
Teague, W. Gerald .
EUROPEAN RESPIRATORY JOURNAL, 2014, 43 (02) :343-373
[5]   The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations [J].
Dunican, Eleanor M. ;
Fahy, John V. .
ANNALS OF THE AMERICAN THORACIC SOCIETY, 2015, 12 :S144-S149
[6]   Type 2 inflammation in asthma - present in most, absent in many [J].
Fahy, John V. .
NATURE REVIEWS IMMUNOLOGY, 2015, 15 (01) :57-65
[7]   Evolving Concepts of Asthma [J].
Gauthier, Marc ;
Ray, Anuradha ;
Wenzel, Sally E. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 192 (06) :660-668
[8]  
GINA pocket guide, 2019, DIAGNOSIS MANAGEMENT
[9]  
Global Initiative for Asthma, 2018, GLOB STRAT ASTHM MAN
[10]   Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma [J].
Peters, Michael C. ;
Mekonnen, Zesemayat K. ;
Yuan, Shaopeng ;
Bhakta, Nirav R. ;
Woodruff, Prescott G. ;
Fahy, John V. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (02) :388-U181