Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii

被引：25

作者：

Cheng, Jiaqi ^{[1
]}

Yan, Jun ^{[1
]}

Reyna, Zeferino ^{[1
]}

Slarve, Matt ^{[1
]}

Lu, Peggy ^{[1
]}

Spellberg, Brad ^{[2
]}

Luna, Brian ^{[1
]}

机构：

[1] USC, Dept Mol Microbiol & Immunol, Keck Sch Med, Los Angeles, CA 90007 USA

[2] Los Angeles Cty USC LAC Usc Med Ctr, Los Angeles, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2021年 / 65卷 / 04期

关键词：

Acinetobacter baumannii; antibiotic resistance; colistin; rifabutin; BACTERIA;

D O I：

10.1128/AAC.02204-20

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recently, we reported rifabutin hyperactivity against Acinetobacter baumannii. We sought to characterize potential interactions between rifabutin and colistin, the last-resort drug for carbapenem-resistant infections. Rifabutin and colistin were synergistic in vitro and in vivo, and low-dose colistin significantly suppressed emergence of resistance to rifabutin. Thus, this combination is a promising therapeutic option for highly resistant A. baumannii infections.

引用

页数：5

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