In vitro interactions between antiretroviral protease inhibitors and artemisinin endoperoxides against Plasmodium falciparum

被引：14

作者：

He, Zhengxiang ^{[1
]}

Chen, Lili ^{[1
]}

You, Jianlan ^{[1
]}

Qin, Li ^{[1
]}

Chen, Xiaoping ^{[1
]}

机构：

[1] Chinese Acad Sci, Lab Pathogen Biol, GIBH, Ctr Infect & Immun, Guangzhou 510663, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2010年 / 35卷 / 02期

关键词：

Antiretroviral protease inhibitors; Artemisinin endoperoxides; Antimalarial; Drug interaction; ANTIMALARIAL; CHLOROQUINE; MALARIA; AGENTS; VIVO; COINFECTION; DISCOVERY; ACRIDONES; HIV;

D O I：

10.1016/j.ijantimicag.2009.09.016

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Antiretroviral protease inhibitors (APIs), which are effective at controlling the effects of human immunodeficiency virus (HIV) in patients, have also proven efficacious in inhibiting Plasmodium falciparum growth in vitro. Use of artemisinin-based combination therapies is being encouraged to reduce malaria mortality in areas of P. falciparum resistance to conventional antimalarial drugs. The aim of this study was to investigate drug interactions between HIV protease inhibitors and artemisinin drugs against malaria. In vitro cultures of P. falciparum provide a screen system for identifying and evaluating drug combinations. The derived isobolograms provide clear evidence of antagonistic interactions between artemisinin endoperoxides and several different APIs. (C) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：191 / 193

页数：3

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