Effect of calcium antagonist on cerebral blood flow and oxygen metabolism in patients with hypertension and chronic major cerebral artery occlusion: a positron emission tomography study

被引：15

作者：

Ogasawara, K

Noda, A

Yasuda, S

Kobayashi, M

Yukawa, H

Ogawa, A

机构：

[1] Iwate Med Univ, Dept Neurosurg, Morioka, Iwate 0208505, Japan

[2] Iwate Med Univ, Cyclotron Res Ctr, Morioka, Iwate 020, Japan

[3] Fujisawa Pharmaceut Co Ltd, Adv Technol Platform Res Lab, Tsukuba, Ibaraki, Japan

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 2003年 / 24卷 / 01期

关键词：

nilvadipine; major cerebral artery occlusion; hypertension; PET;

D O I：

10.1097/00006231-200301000-00017

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

To evaluate the effect of a calcium antagonist, nilvadipine, on cerebral blood flow and oxygen metabolism, we prospectively examined five ischaemic stroke patients, with both hypertension and chronic major cerebral artery occlusion, using positron emission tomography. The blood pressure showed a significant decrease after 3 months of nilvadipine treatment, the cerebral blood flow in the affected regions showed a significant increase and the oxygen extraction fraction showed a significant decrease. We conclude that nilvadipine is a safe and effective anti-hypertensive agent for patients with both hypertension and chronic major cerebral artery occlusion. ((C) 2003 Lippincott Williams Wilkins).

引用

页码：71 / 76

页数：6

共 32 条

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