Metal is not inert: Role of metal ions released by biocorrosion in aseptic loosening-Current concepts

被引：124
作者：
Cadosch, Dieter [1 ,2 ]
Chan, Erwin [1 ]
Gautschi, Oliver P. [1 ,2 ]
Filgueira, Luis [1 ]
机构：
[1] Univ Western Australia, Sch Anat & Human Biol, Crawley, Australia
[2] Royal Perth Hosp, Dept Orthopaed & Trauma Surg, Perth, WA, Australia
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2009年 / 91A卷 / 04期
关键词：
metal implants; biocorrosion; metal ions; aseptic loosening; immunoreactivity; TOTAL HIP-ARTHROPLASTY; TOTAL JOINT REPLACEMENT; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; BONE-RESORBING CELLS; IN-VITRO; OSTEOCLAST DIFFERENTIATION; ORTHOPEDIC IMPLANTS; ALLERGIC REACTIONS; STAINLESS-STEEL;
D O I：
10.1002/jbm.a.32625
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Metal implants are essential therapeutic tools for the treatment of bone fractures and joint replacements. The metals and metal alloys used in contemporary orthopedic and trauma Surgery are well tolerated by the majority of patients. However, complications resulting from inflammatory and immune reactions to metal implants have been welt documented. This review briefly discusses the different mechanisms of metal implant corrosion in the human body, which lead to the release of significant levels of metal ions into the peri-implant tissues and the systemic blood circulation. Additionally, this article reviews the effects of the released ions on bone metabolism and the immune system and discusses their involvement in the pathophysiological mechanisms of aseptic loosening and metal hypersensitivity in patients with metal implants. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 1252-1262,2009
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收藏
页码：1252 / 1262
页数：11
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