Circadian variation on oxygen consumption in preterm infants

被引:8
作者
Bauer, Jacqueline [1 ]
Janecke, Andreas [2 ]
Gerss, Joachim [3 ]
Masjosthusmann, Katja [1 ]
Werner, Claudius [1 ]
Hoffmann, Georg [4 ]
机构
[1] Univ Hosp Muenster, Dept Pediat, D-48149 Munster, Germany
[2] Univ Innsbruck, Inst Med Biol & Human Genet, A-6020 Innsbruck, Austria
[3] Univ Munster, Inst Med Informat & Biomath, Munster, Germany
[4] Univ Heidelberg, Dept Pediat, D-6900 Heidelberg, Germany
关键词
Circadian variation; oxygen consumption; preterm infants; BIRTH-WEIGHT INFANTS; ENERGY-EXPENDITURE; METABOLIC-RATE; PREMATURE-INFANTS; PHYSICAL-ACTIVITY; NEONATAL SLEEP; RHYTHMS; BALANCE; PERIODS;
D O I
10.1515/JPM.2009.067
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: We investigated the diurnal variation in oxygen consumption to determine the optimal time periods of calorimetry in preterm infants. Methods: Oxygen consumption (VO(2)) was measured continuously for 24 h using indirect calorimetry. Twenty-two premature infants with gestational age of 27-31 (31 +/- 1.7) weeks were enrolled in the study. Heart rate, respiratory rate, oxygen saturation, skin and rectal temperature and physical activity were monitored continuously. Results: The averaged values of VO(2) showed a significant pattern (P<0.0001) of circadian rhythm with a peak in the afternoon and a nadir during the night with significantly differences between the mean VO(2) values. A circadian variation of VO(2) was found in more than 80% of preterm infants and was unrelated to gestational age, physical activity or environmental stress. The infants spent 90.4% of their time sleeping. Conclusions: These findings indicate the possible existence of an endogenous circadian rhythm of VO(2) in preterm infants beginning shortly after birth. Day-night variations of VO(2) should be considered when VO(2) values are extrapolated from short measurement periods to prevent overestimation of values.
引用
收藏
页码:413 / 417
页数:5
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