Glucocorticoid receptor dynamics and gene regulation

被引：56

作者：

Biddie, Simon C. ^{[1
,2
]}

Hager, Gordon L. ^{[1
]}

机构：

[1] NCI, Lab Receptor Biol & Gene Express, NIH, Bethesda, MD 20892 USA

[2] Univ Bristol, Dept Med, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol BS1 3NY, Avon, England

来源：

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS | 2009年 / 12卷 / 03期

关键词：

Glucocorticoid receptor; chromatin; dynamics; gene expression; TUMOR VIRUS PROMOTER; NF-KAPPA-B; LONG TERMINAL REPEAT; ESTROGEN-RECEPTOR; IN-VIVO; TRANSCRIPTIONAL ACTIVATION; TRANSACTIVATION DOMAIN; MOLECULAR CHAPERONE; CHROMATIN DYNAMICS; ANDROGEN RECEPTOR;

D O I：

10.1080/10253890802506409

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The glucocorticoid receptor regulates the expression of a large number of genes in mammalian cells. The interaction of this receptor with regulatory elements has been discovered to be highly dynamic, with occupancy states measured in seconds, rather than minutes or hours. This finding has led to a paradigm shift in our understanding of receptor function throughout the genome. The mechanisms involved in these rapid exchange events, as well as the implications for receptor function, are discussed.

引用

页码：193 / 205

页数：13

共 109 条

[51] Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2 [J].

Ichinose, H ;

Garnier, JM ;

Chambon, P ;

Losson, R .

GENE, 1997, 188 (01) :95-100

[52]

JOHN S, 2008, ENDOCRINOLOGY UNPUB

[53] Interaction of the glucocorticoid receptor with the chromatin landscape [J].

John, Sam ;

Sabo, Peter J. ;

Johnson, Thomas A. ;

Sung, Myong-Hee ;

Biddie, Simon C. ;

Lightman, Stafford L. ;

Voss, Ty C. ;

Davis, Sean R. ;

Meltzer, Paul S. ;

Stamatoyannopoulos, John A. ;

Hager, Gordon L. .

MOLECULAR CELL, 2008, 29 (05) :611-624

[54] The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter [J].

Kang, KI ;

Meng, X ;

Devin-Leclerc, J ;

Bouhouche, I ;

Chadli, A ;

Cadepond, F ;

Baulieu, EE ;

Catelli, MG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) :1439-1444

[55] New twists in gene regulation by glucocorticoid receptor: Is DNA binding dispensable? [J].

Karin, M .

CELL, 1998, 93 (04) :487-490

[56] Glucocorticoid receptor domain requirements for chromatin remodeling and transcriptional activation of the mouse mammary tumor virus promoter in different nucleoprotein contexts [J].

Keeton, EK ;

Fletcher, TM ;

Baumann, CT ;

Hager, GL ;

Smith, CL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (31) :28247-28255

[57] BRG1 CONTAINS A CONSERVED DOMAIN OF THE SWI2/SNF2 FAMILY NECESSARY FOR NORMAL MITOTIC GROWTH AND TRANSCRIPTION [J].

KHAVARI, PA ;

PETERSON, CL ;

TAMKUN, JW ;

MENDEL, DB ;

CRABTREE, GR .

NATURE, 1993, 366 (6451) :170-174

[58] Proteasome activity modulates chromatin modifications and RNA polymerase II phosphorylation to enhance glucocorticoid receptor-mediated transcription [J].

Kinyamu, H. Karimi ;

Archer, Trevor K. .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (13) :4891-4904

[59]

Kitchener P, 2004, EUR J NEUROSCI, V19, P1837, DOI 10.1111/j.1460-9568.2004.03267.x

[60] Ligand-specific dynamics of the androgen receptor at its response element in living cells [J].

Klokk, Tove I. ;

Kurys, Piotr ;

Elbi, Cem ;

Nagaich, Akhilesh K. ;

Hendarwanto, Anindya ;

Slagsvold, Thomas ;

Chang, Ching-Yi ;

Hager, Gordon L. ;

Saatcioglu, Fahri .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (05) :1823-1843

← 1 2 3 4 5 6 7 8 9 10 →