Glucocorticoid receptor dynamics and gene regulation

被引：55
|
作者：
Biddie, Simon C. [1 ,2 ]
Hager, Gordon L. [1 ]
机构：
[1] NCI, Lab Receptor Biol & Gene Express, NIH, Bethesda, MD 20892 USA
[2] Univ Bristol, Dept Med, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol BS1 3NY, Avon, England
来源：
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS | 2009年 / 12卷 / 03期
关键词：
Glucocorticoid receptor; chromatin; dynamics; gene expression; TUMOR VIRUS PROMOTER; NF-KAPPA-B; LONG TERMINAL REPEAT; ESTROGEN-RECEPTOR; IN-VIVO; TRANSCRIPTIONAL ACTIVATION; TRANSACTIVATION DOMAIN; MOLECULAR CHAPERONE; CHROMATIN DYNAMICS; ANDROGEN RECEPTOR;
D O I：
10.1080/10253890802506409
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The glucocorticoid receptor regulates the expression of a large number of genes in mammalian cells. The interaction of this receptor with regulatory elements has been discovered to be highly dynamic, with occupancy states measured in seconds, rather than minutes or hours. This finding has led to a paradigm shift in our understanding of receptor function throughout the genome. The mechanisms involved in these rapid exchange events, as well as the implications for receptor function, are discussed.
引用
收藏
页码：193 / 205
页数：13
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