Evolution of pathogenicity and sexual reproduction in eight Candida genomes

被引：767

作者：

Butler, Geraldine ^{[2
]}

Rasmussen, Matthew D. ^{[3
]}

Lin, Michael F. ^{[1
,3
]}

Santos, Manuel A. S. ^{[4
,5
]}

Sakthikumar, Sharadha ^{[1
]}

Munro, Carol A. ^{[6
]}

Rheinbay, Esther ^{[3
,7
]}

Grabherr, Manfred ^{[1
]}

Forche, Anja ^{[8
]}

Reedy, Jennifer L. ^{[9
]}

Agrafioti, Ino ^{[10
]}

Arnaud, Martha B. ^{[11
]}

Bates, Steven ^{[12
]}

Brown, Alistair J. P. ^{[6
]}

Brunke, Sascha ^{[13
]}

Costanzo, Maria C. ^{[11
]}

Fitzpatrick, David A. ^{[2
]}

de Groot, Piet W. J. ^{[14
]}

Harris, David ^{[15
]}

Hoyer, Lois L. ^{[16
]}

Hube, Bernhard ^{[13
]}

Klis, Frans M. ^{[14
]}

Kodira, Chinnappa ^{[1
]}

Lennard, Nicola ^{[15
]}

Logue, Mary E. ^{[2
]}

Martin, Ronny ^{[13
]}

Neiman, Aaron M. ^{[17
]}

Nikolaou, Elissavet ^{[6
]}

Quail, Michael A. ^{[15
]}

Quinn, Janet ^{[18
]}

Santos, Maria C. ^{[4
,5
]}

Schmitzberger, Florian F. ^{[11
]}

Sherlock, Gavin ^{[11
]}

Shah, Prachi ^{[11
]}

Silverstein, Kevin A. T. ^{[19
]}

Skrzypek, Marek S. ^{[11
]}

Soll, David ^{[20
]}

Staggs, Rodney ^{[19
]}

Stansfield, Ian ^{[6
]}

Stumpf, Michael P. H. ^{[10
]}

Sudbery, Peter E. ^{[21
]}

Srikantha, Thyagarajan ^{[20
]}

Zeng, Qiandong ^{[1
]}

Berman, Judith ^{[8
]}

Berriman, Matthew ^{[15
]}

Heitman, Joseph ^{[9
]}

Gow, Neil A. R. ^{[6
]}

Lorenz, Michael C. ^{[22
]}

Birren, Bruce W. ^{[1
]}

Kellis, Manolis ^{[1
,3
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Univ Coll Dublin, Conway Inst, UCD Sch Biomol & Biomed Sci, Dublin 4, Ireland

[3] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA

[4] Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal

[5] Univ Aveiro, CESAM, P-3810193 Aveiro, Portugal

[6] Univ Aberdeen, Inst Med Sci, Sch Med Sci, Aberdeen AB25 2ZD, Scotland

[7] Boston Univ, Bioinformat Program, Boston, MA 02215 USA

[8] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

[9] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[10] Univ London Imperial Coll Sci Technol & Med, Ctr Bioinformat, London SW7 2AY, England

[11] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[12] Univ Exeter, Sch Biosci, Exeter EX4 4QD, Devon, England

[13] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, Dept Microbial Pathogen Mech, D-07745 Jena, Germany

[14] Univ Amsterdam, Swammerdam Inst Life Sci, NL-1090 GB Amsterdam, Netherlands

[15] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

[16] Univ Illinois, Dept Pathobiol, Urbana, IL 61802 USA

[17] SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA

[18] Univ Newcastle, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[19] Univ Minnesota, Mason Canc Ctr, Biostat & Bioinformat Grp, Minneapolis, MN 55455 USA

[20] Univ Iowa, Dept Biol, Iowa City, IA 52242 USA

[21] Univ Sheffield, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England

[22] Univ Texas Hlth Sci Ctr Houston, Dept Microbiol & Mol Genet, Houston, TX 77030 USA

来源：

NATURE | 2009年 / 459卷 / 7247期

基金：

美国国家科学基金会; 英国惠康基金; 美国国家卫生研究院; 爱尔兰科学基金会; 英国生物技术与生命科学研究理事会;

关键词：

ALBICANS GENOME; MATING-TYPE; SEQUENCE; YEASTS; VIRULENCE; LODDEROMYCES; PARAPSILOSIS; MEIOSIS; FAMILY; CODON;

D O I：

10.1038/nature08064

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the alpha 1/alpha 2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.

引用

页码：657 / 662

页数：6

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