Fight to the bitter end: DNA repair and aging

被引：37

作者：

Chen, Yu ^{[1
]}

Geng, Anke ^{[1
]}

Zhang, Weina ^{[1
]}

Qian, Zhen ^{[1
]}

Wan, Xiaoping ^{[1
]}

Jiang, Ying ^{[1
]}

Mao, Zhiyong ^{[1
]}

机构：

[1] Tongji Univ, Clin & Translat Res Ctr, Sch Life Sci & Technol,Shanghai Key Lab Signaling, Frontier Sci Ctr Stem Cell Res,Shanghai First Mat, Shanghai 200092, Peoples R China

来源：

AGEING RESEARCH REVIEWS | 2020年 / 64卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

DNA repair; Aging; Senescence; Inflammation; Rejuvenation; DNA repair reporter cassette; BASE EXCISION-REPAIR; DOUBLE-STRAND BREAKS; HEMATOPOIETIC STEM-CELLS; INDUCED HOMOLOGOUS RECOMBINATION; PROMOTES GENOMIC STABILITY; WERNER-SYNDROME PROTEIN; EXTENDS LIFE-SPAN; CYCLIC GMP-AMP; SENESCENT CELLS; DAMAGE RESPONSE;

D O I：

10.1016/j.arr.2020.101154

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and development and for human health. DNA repair is a fundamental and conserved mechanism responsible for mending damaged DNA and restoring genomic stability, while its deficiency is closely related to multiple human disorders. In recent years, remarkable progress has been made in the field of DNA repair and aging. Here, we will extensively discuss the relationship among DNA damage, DNA repair, aging and aging-associated diseases based on the latest research. In addition, the possible role of DNA repair in several potential rejuvenation strategies will be discussed. Finally, we will also review the emerging methods that may facilitate future research on DNA repair.

引用

页数：19

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