The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets

被引：40
作者：
Ryu, Juhee [1 ,2 ,3 ,4 ]
Ahn, Youngkeun [1 ,5 ]
Kook, Hyun [1 ,2 ,4 ]
Kim, Young-Kook [1 ,2 ,3 ]
机构：
[1] Chonnam Natl Univ, Basic Res Lab Vasc Remodeling, Sch Med, Jeollanam Do, South Korea
[2] Chonnam Natl Univ, Dept Biomed Sci, Ctr Creat Biomed Scientists, Jeollanam Do, South Korea
[3] Chonnam Natl Univ, Dept Biochem, Sch Med, Jeollanam Do, South Korea
[4] Chonnam Natl Univ, Dept Pharmacol, Sch Med, Jeollanam Do, South Korea
[5] Chonnam Natl Univ Hosp, Dept Cardiol, Cardiovasc Ctr, Gwangju, South Korea
来源：
PHARMACOLOGY & THERAPEUTICS | 2021年 / 218卷
基金：
新加坡国家研究基金会;
关键词：
Non-coding RNA; microRNA; Long non-coding RNA; Circular RNA; Vascular calcification; Valvular calcification; MUSCLE-CELL CALCIFICATION; MESENCHYMAL STEM-CELLS; OSTEOBLAST DIFFERENTIATION; IN-VITRO; AORTIC CALCIFICATION; DOWN-REGULATION; CIRCULAR RNAS; UP-REGULATION; OSTEOGENIC DIFFERENTIATION; CORONARY CALCIFICATION;
D O I：
10.1016/j.pharmthera.2020.107675
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Vascular calcification (VC) is characterized by an accumulation of calcium phosphate crystals inside the vessel wall. VC is often associated with diabetes, chronic kidney disease (CKD), atherosclerosis, and cardiovascular disease (CVD). Even though the number of patients with VC remains prevalent. there are still no approved therapies for the treatment of VC. Since the pathogenesis of VC is diverse and involves multiple factors and mechanisms, it is critical to reveal the novel mechanisms involved in VC. Although protein-coding RNAs involved in VC have been extensively studied, the roles of non-coding RNAs (ncRNAs) are not yet fully understood. The field of ncRNAs has recently received attention, and accumulating evidence from studies in VC suggests that ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in the regulation of VC. NcRNAs can modulate VC by acting as promoters or inhibitors and may be useful in the clinical diagnosis and treatment of VC. In this article, we review and discuss ncRNAs that regulate VC and present the therapeutic implications of these ncRNAs. (C) 2020 Elsevier Inc. All rights reserved.
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页数：15
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