B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome

被引：80

作者：

Ingebrigtsen, Vibeke A. ^{[1
,2
]}

Boye, Kjetil ^{[1
,3
]}

Nesland, Jahn M. ^{[2
,4
]}

Nesbakken, Arild ^{[2
,6
]}

Flatmark, Kjersti ^{[1
,5
]}

Fodstad, Oystein ^{[1
,2
]}

机构：

[1] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Tumor Biol, N-0424 Oslo, Norway

[2] Univ Oslo, Fac Med, Inst Clin Med, N-0318 Oslo, Norway

[3] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Oncol, N-0424 Oslo, Norway

[4] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Pathol, N-0424 Oslo, Norway

[5] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Surg Gastroenterol, N-0424 Oslo, Norway

[6] Oslo Univ Hosp, Dept Gastrointestinal Surg, N-0424 Oslo, Norway

来源：

BMC CANCER | 2014年 / 14卷

关键词：

Colorectal cancer; Nuclear B7-H3; Prognostic biomarker; Tissue microarray; COSTIMULATORY MOLECULE B7-H3; MICROSATELLITE INSTABILITY; COLON-CANCER; LIGAND EXPRESSION; PROSTATE-CANCER; TUMOR-CELL; STAGE-II; SURVIVAL; SENSITIVITY; PROGNOSIS;

D O I：

10.1186/1471-2407-14-602

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: We have previously reported overexpression of the immunoregulatory protein B7-H3 in colorectal cancer and that nuclear expression predicted poor outcome in colon cancer patients. The present study was performed to examine the prognostic role of B7-H3 in an independent colorectal cancer cohort. Methods: Using tissue microarrays from 731 colorectal cancer patients, tumour B7-H3 expression was assessed by immunohistochemistry. Associations with clinicopathological parameters and patient outcome were investigated. Results: Nuclear expression of B7-H3 in cancer cells was present in 27% of the samples in the total study cohort, while cytoplasmic/membrane and stromal expression was seen in 86% and 77% of the samples, respectively. Nuclear B7-H3 had no prognostic relevance in the complete outcome cohort, neither in colon cancer patients. However, nuclear B7-H3 was significantly associated with reduced recurrence-free survival in TNM stage I colorectal cancer patients. Conclusions: Overexpression of B7-H3 in colorectal cancer was confirmed, but in contrast to previous results, nuclear B7-H3 was not a strong prognostic biomarker in this cohort. The discrepancy might be related to the use of single-core tissue microarrays for detection of the heterogeneously expressed B7-H3, and the role of B7-H3 in colorectal cancer still needs further examination.

引用

页数：9

共 42 条

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