Report of an HIV and HHV-8 negative case of primary effusion lymphoma with idiopathic T4 lymphocytopenia

被引：17
作者：
Tsagarakis, Nikolaos J. [1 ]
Argyrou, Aspasia [2 ]
Gortzolidis, Georgios [2 ]
Kentrou, Nektaria [1 ]
Papadhimitriou, Stefanos I. [3 ]
Tzanetou, Konstantina [4 ]
Kakiopoulos, Georgios [5 ]
Papadimitriou, Konstantinos A. [1 ]
Skoumi, Dimitra [1 ]
Paterakis, Georgios [1 ]
机构：
[1] Athens Reg Gen Hosp G Gennimatas, Dept Immunol, Flow Cytometry Lab, Athens 11527, Greece
[2] Athens Reg Gen Hosp G Gennimatas, Dept Clin Hematol, Athens 11527, Greece
[3] Athens Reg Gen Hosp G Gennimatas, Dept Lab Hematol, Athens 11527, Greece
[4] Athens Reg Gen Hosp G Gennimatas, Dept Microbiol, Athens 11527, Greece
[5] Athens Reg Gen Hosp G Gennimatas, Dept Pathol, Athens 11527, Greece
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2009年 / 90卷 / 01期
关键词：
Primary effusion lymphoma; HIV and HHV-8/KSHV negative; Idiopathic T4 lymphocytopenia; HEPATITIS-C VIRUS; GENE-EXPRESSION PROFILE; LIVER-CIRRHOSIS; HERPES-VIRUS; DNA-SEQUENCES; PATIENT; IMMUNODEFICIENCY; PEL; DERIVATION; PHENOTYPE;
D O I：
10.1007/s12185-009-0343-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although primary effusion lymphoma (PEL) is usually associated with human herpes virus-8/Kaposi sarcoma herpes virus (HHV-8/KSHV) and human immunodeficiency virus (HIV), there are several reports of HHV-8/KSHV and HIV negative cases, mainly in the setting of immunodeficiency. Here, we report the second case of PEL associated with idiopathic T4 lymphocytopenia (ICL), which was HHV-8/KSHV negative, HIV negative and Epstein-Barr virus positive, while no other causative agents for immunodeficiency were documented. Flow cytometry revealed a hyperdiploid and highly mitotic large B-cell population, CD30, EMA, CD66, CD38 and CD71 positive. The malignant lymphoma cells showed atypia with prominent nuclei and basophilic vacuolated cytoplasm, while cytogenetic analysis with fluorescent in situ hybridization showed trisomy 18. The patient was administered R-COP chemotherapy, but no remission was achieved, up to 3 months from diagnosis.
引用
收藏
页码：94 / 98
页数：5
相关论文
共 50 条
  • [41] Primary effusion lymphoma of T-cell origin with t(7;8)(q32;q13) in an HIV-negative patient with HCV-related liver cirrhosis and hepatocellular carcinoma positive for HHV6 and HHV8
    Shoko Nakayama-Ichiyama
    Taiji Yokote
    Kichinosuke Kobayashi
    Yuji Hirata
    Nobuya Hiraoka
    Kazuki Iwaki
    Ayami Takayama
    Toshikazu Akioka
    Satoko Oka
    Takuji Miyoshi
    Hideo Fukui
    Yasuhiro Tsuda
    Takayuki Takubo
    Motomu Tsuji
    Kazuhide Higuchi
    Toshiaki Hanafusa
    Annals of Hematology, 2011, 90 : 1229 - 1231
  • [42] Primary effusion lymphoma of T-cell origin with t(7;8)(q32;q13) in an HIV-negative patient with HCV-related liver cirrhosis and hepatocellular carcinoma positive for HHV6 and HHV8
    Nakayama-Ichiyama, Shoko
    Yokote, Taiji
    Kobayashi, Kichinosuke
    Hirata, Yuji
    Hiraoka, Nobuya
    Iwaki, Kazuki
    Takayama, Ayami
    Akioka, Toshikazu
    Oka, Satoko
    Miyoshi, Takuji
    Fukui, Hideo
    Tsuda, Yasuhiro
    Takubo, Takayuki
    Tsuji, Motomu
    Higuchi, Kazuhide
    Hanafusa, Toshiaki
    ANNALS OF HEMATOLOGY, 2011, 90 (10) : 1229 - 1231
  • [43] Solid variant of primary effusion lymphoma in successfully treated HIV infection: a case report
    Mylona, E.
    Baraboutis, I. G.
    Georgiou, O.
    Rondogianni, D.
    Lekakis, L. J.
    Papastamopoulos, V.
    Apostolidis, I.
    Skoutelis, A. T.
    INTERNATIONAL JOURNAL OF STD & AIDS, 2008, 19 (08) : 570 - 572
  • [44] Primary effusion lymphoma in a human immunodeficiency virus-negative patient with unexpected unusual complications: a case report
    Fernandez-Trujillo, Liliana
    Bolanos, John E.
    Velasquez, Mauricio
    Garcia, Carlos
    Sua, Luz F.
    JOURNAL OF MEDICAL CASE REPORTS, 2019, 13 (01)
  • [45] An unusual case of Primary Effusion Lymphoma with aberrant T-cell phenotype in a HIV-negative, HBV -positive, cirrhotic patient, and review of the literature
    Nepka, Charitini
    Kanakis, Dimitrios
    Samara, Maria
    Kapsoritakis, Andreas
    Potamianos, Spyridon
    Karantana, Maria
    Koukoulis, Georgios
    CYTOJOURNAL, 2012, 9
  • [46] Primary HHV-8 (-) Effusion-Based Non-Germinal Center B Cell Diffuse Large B Cell Lymphoma Successfully Treated with Standard Anthracycline-Based Chemoimmunotherapy
    Kuhlman, Justin
    Moustafa, Muhamad Alhaj
    Jiang, Liuyan
    Tun, Han W.
    JOURNAL OF BLOOD MEDICINE, 2021, 12 : 833 - 838
  • [47] Ultrastructure of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8) in a primary effusion lymphoma cell line treated with tetradecanoyl phorbol acetate (TPA)
    Yuji Ohtsuki
    Jun Iwata
    Mutsuo Furihata
    Tamotsu Takeuchi
    Hiroshi Sonobe
    Isao Miyoshi
    Y. Ohtsuki
    J. Iwata
    M. Furihata
    T. Takeuchi
    H. Sonobe
    I. Miyoshi
    Medical Electron Microscopy, 1999, 32 (2): : 94 - 99
  • [48] Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir
    Laura Campogiani
    Carlotta Cerva
    Gaetano Maffongelli
    Elisabetta Teti
    Livio Pupo
    Sara Vaccarini
    Maria Cantonetti
    Alfredo Pennica
    Massimo Andreoni
    Loredana Sarmati
    AIDS Research and Therapy, 16
  • [49] Human herpesvirus-8-positive primary effusion lymphoma in HIV-negative patients: Single institution case series with a multidisciplinary characterization
    Rossi, Giovanni
    Cozzi, Ilaria
    Della Starza, Irene
    De Novi, Lucia Anna
    De Propris, Maria Stefania
    Gaeta, Aurelia
    Petrucci, Luigi
    Pulsoni, Alessandro
    Pulvirenti, Federica
    Ascoli, Valeria
    CANCER CYTOPATHOLOGY, 2021, 129 (01) : 62 - 74
  • [50] Manifestations of three HHV-8-related diseases in an HIV-negative patient: Immunoblastic variant multicentric Castleman's disease, primary effusion lymphoma, and Kaposi's sarcoma
    Codish, S
    Abu-Shakra, M
    Ariad, S
    Zirkin, HJ
    Yermiyahu, T
    Dupin, N
    Boshoff, C
    Sukenik, S
    AMERICAN JOURNAL OF HEMATOLOGY, 2000, 65 (04) : 310 - 314
12345