Report of an HIV and HHV-8 negative case of primary effusion lymphoma with idiopathic T4 lymphocytopenia

被引：17
|
作者：
Tsagarakis, Nikolaos J. [1 ]
Argyrou, Aspasia [2 ]
Gortzolidis, Georgios [2 ]
Kentrou, Nektaria [1 ]
Papadhimitriou, Stefanos I. [3 ]
Tzanetou, Konstantina [4 ]
Kakiopoulos, Georgios [5 ]
Papadimitriou, Konstantinos A. [1 ]
Skoumi, Dimitra [1 ]
Paterakis, Georgios [1 ]
机构：
[1] Athens Reg Gen Hosp G Gennimatas, Dept Immunol, Flow Cytometry Lab, Athens 11527, Greece
[2] Athens Reg Gen Hosp G Gennimatas, Dept Clin Hematol, Athens 11527, Greece
[3] Athens Reg Gen Hosp G Gennimatas, Dept Lab Hematol, Athens 11527, Greece
[4] Athens Reg Gen Hosp G Gennimatas, Dept Microbiol, Athens 11527, Greece
[5] Athens Reg Gen Hosp G Gennimatas, Dept Pathol, Athens 11527, Greece
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2009年 / 90卷 / 01期
关键词：
Primary effusion lymphoma; HIV and HHV-8/KSHV negative; Idiopathic T4 lymphocytopenia; HEPATITIS-C VIRUS; GENE-EXPRESSION PROFILE; LIVER-CIRRHOSIS; HERPES-VIRUS; DNA-SEQUENCES; PATIENT; IMMUNODEFICIENCY; PEL; DERIVATION; PHENOTYPE;
D O I：
10.1007/s12185-009-0343-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although primary effusion lymphoma (PEL) is usually associated with human herpes virus-8/Kaposi sarcoma herpes virus (HHV-8/KSHV) and human immunodeficiency virus (HIV), there are several reports of HHV-8/KSHV and HIV negative cases, mainly in the setting of immunodeficiency. Here, we report the second case of PEL associated with idiopathic T4 lymphocytopenia (ICL), which was HHV-8/KSHV negative, HIV negative and Epstein-Barr virus positive, while no other causative agents for immunodeficiency were documented. Flow cytometry revealed a hyperdiploid and highly mitotic large B-cell population, CD30, EMA, CD66, CD38 and CD71 positive. The malignant lymphoma cells showed atypia with prominent nuclei and basophilic vacuolated cytoplasm, while cytogenetic analysis with fluorescent in situ hybridization showed trisomy 18. The patient was administered R-COP chemotherapy, but no remission was achieved, up to 3 months from diagnosis.
引用
收藏
页码：94 / 98
页数：5
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