A novel method for removal of deep brain stimulation artifact from electroencephalography

被引:27
作者
Sun, Yinming [1 ]
Farzan, Faranak [1 ]
Dominguez, Luis Garcia [1 ]
Barr, Mera S. [1 ]
Giacobbe, Peter [2 ]
Lozano, Andres M. [3 ]
Wong, Willy [4 ]
Daskalakis, Zafiris J. [1 ]
机构
[1] Univ Toronto, Ctr Addict & Mental Hlth, Temerty Ctr Therapeut Brain Intervent, Toronto, ON, Canada
[2] Univ Toronto, Toronto Gen Hosp, Dept Psychiat, Toronto, ON M5G 1L7, Canada
[3] Univ Toronto, Univ Hlth Network, Dept Neurosurg, Toronto, ON, Canada
[4] Univ Toronto, Dept Elect & Comp Engn, Toronto, ON, Canada
基金
加拿大健康研究院;
关键词
Deep brain stimulation; Electroencephalography; Artifact removal; Matched filter; PARKINSONS-DISEASE; IMPROVEMENT; DEPRESSION; EEG;
D O I
10.1016/j.jneumeth.2014.09.002
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Background: Deep brain stimulation (DBS) has treatment efficacy in neurological and psychiatric disorders such as Parkinson's disease and major depression. Electroencephalography (EEG) is a versatile neurophysiological tool that can be used to better understand DBS treatment mechanisms. DBS causes artifacts in EEG recordings that preclude meaningful neurophysiological activity from being quantified during stimulation. New method: In this study, we modeled the DBS stimulation artifact and illustrated a technique for removing the artifact using matched filters. The approach was validated using a synthetically generated DBS artifact superimposed on EEG data. Mean squared error (MSE) between the recovered signal and the artifact-free signal was used to quantify the effectiveness of the approach. Results: The DBS artifact was characterized by a series of narrow band components at the harmonic frequencies of DBS stimulation. The filtering approach successfully removed the DBS artifact with MSE value being less than 2% of base signal power for the typical stimulation and recording setups. General guidelines on how to setup DBS EEG studies and configure the subsequent artifact removal process are described. Comparison with previous method: To avoid stimulus artifacts, a number of EEG studies with DBS subjects have resorted to turning the stimulator off during recording, while other studies have used low pass filters to remove artifacts and look at frequencies well below 50 Hz. Conclusions: This study establishes a method through which DBS artifact in EEG recordings can be reliably eliminated, thereby preserving a meaningful neurophysiological signal through which to better understand DBS treatment mechanisms. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:33 / 40
页数:8
相关论文
共 17 条
[1]   Effects of DBS on Auditory and Somatosensory Processing in Parkinson's Disease [J].
Airaksinen, Katja ;
Makela, Jyrki P. ;
Taulu, Samu ;
Ahonen, Antti ;
Nurminen, Jussi ;
Schnitzler, Alfons ;
Pekkonen, Eero .
HUMAN BRAIN MAPPING, 2011, 32 (07) :1091-1099
[2]   Suppression of deep brain stimulation artifacts from the electroencephalogram by frequency-domain Hampel filtering [J].
Allen, David P. ;
Stegemoeller, Elizabeth L. ;
Zadikoff, Cindy ;
Rosenow, Joshua M. ;
MacKinnon, Colum D. .
CLINICAL NEUROPHYSIOLOGY, 2010, 121 (08) :1227-1232
[3]  
[Anonymous], 2005, Electric fields of the brain: The neurophysics of eeg
[4]  
[Anonymous], 1977, DISCRETE TIME SIGNAL
[5]   Potentiation of Gamma Oscillatory Activity through Repetitive Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex [J].
Barr, Mera S. ;
Farzan, Faranak ;
Rusjan, Pablo M. ;
Chen, Robert ;
Fitzgerald, Paul B. ;
Daskalakis, Zafiris J. .
NEUROPSYCHOPHARMACOLOGY, 2009, 34 (11) :2359-2367
[6]   Frontal Theta Cordance Predicts 6-Month Antidepressant Response to Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression: A Pilot Study [J].
Broadway, James M. ;
Holtzheimer, Paul E. ;
Hilimire, Matthew R. ;
Parks, Nathan A. ;
DeVylder, Jordan E. ;
Mayberg, Helen S. ;
Corballis, Paul M. .
NEUROPSYCHOPHARMACOLOGY, 2012, 37 (07) :1764-1772
[7]  
Cacioppo JT, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P1, DOI 10.2277/ 0521844711
[8]   Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold [J].
Cavanagh, James F. ;
Wiecki, Thomas V. ;
Cohen, Michael X. ;
Figueroa, Christina M. ;
Samanta, Johan ;
Sherman, Scott J. ;
Frank, Michael J. .
NATURE NEUROSCIENCE, 2011, 14 (11) :1462-U140
[9]   A randomized trial of deep-brain stimulation for Parkinson's disease [J].
Deuschl, Guenther ;
Schade-Brittinger, Carmen ;
Krack, Paul ;
Volkmann, Jens ;
Schaefer, Helmut ;
Boetzel, Kai ;
Daniels, Christine ;
Deutschlaender, Angela ;
Dillmann, Ulrich ;
Eisner, Wilhelm ;
Gruber, Doreen ;
Hamel, Wolfgang ;
Herzog, Jan ;
Hilker, Ruediger ;
Klebe, Stephan ;
Kloss, Manja ;
Koy, Jan ;
Krause, Martin ;
Kupsch, Andreas ;
Lorenz, Delia ;
Lorenzl, Stefan ;
Mehdorn, H. Maximilian ;
Moringlane, Jean Richard ;
Oertel, Wolfgang ;
Pinsker, Marcus O. ;
Reichmann, Heinz ;
Reuss, Alexander ;
Schneider, Gerd-Helge ;
Schnitzler, Alfons ;
Steude, Ulrich ;
Sturm, Volker ;
Timmermann, Lars ;
Tronnier, Volker ;
Trottenberg, Thomas ;
Wojtecki, Lars ;
Wolf, Elisabeth ;
Poewe, Werner ;
Voges, Juergen .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) :896-908
[10]   Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Unipolar and Bipolar Depression [J].
Holtzheimer, Paul E. ;
Kelley, Mary E. ;
Gross, Robert E. ;
Filkowski, Megan M. ;
Garlow, Steven J. ;
Barrocas, Andrea ;
Wint, Dylan ;
Craighead, Margaret C. ;
Kozarsky, Julie ;
Chismar, Ronald ;
Moreines, Jared L. ;
Mewes, Klaus ;
Posse, Patricio Riva ;
Gutman, David A. ;
Mayberg, Helen S. .
ARCHIVES OF GENERAL PSYCHIATRY, 2012, 69 (02) :150-158