Synthesis of Unnatural Amino Acids Functionalized with Sterically Shielded Pyrroline Nitroxides

被引：47

作者：

Wang, Ying ^{[1
]}

Paletta, Joseph T. ^{[1
]}

Berg, Kathleen ^{[1
]}

Reinhart, Erin ^{[1
]}

Rajca, Suchada ^{[1
]}

Rajca, Andrzej ^{[1
]}

机构：

[1] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 20期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

SPIN-LABEL; DISTANCE MEASUREMENTS; REDUCTION; PROTEINS; KINETICS; PROBES;

D O I：

10.1021/ol502449r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of unnatural amino acids functionalized with sterically shielded pyrroline nitroxides were synthesized. Their reduction by ascorbate/glutathione indicates that l-cysteine functionalized with gem-diethylpyrroline nitroxide is reduced at the slowest rate and is comparable to that measured for the most resistant to reduction pyrroline and pyrrolidine nitroxides.

引用

收藏

页码：5298 / 5300

页数：3

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