Heart targeted nanoliposomal/nanoparticles drug delivery: An updated review

被引:49
作者
Cheraghi, Mostafa [1 ]
Negahdari, Babak [2 ]
Daraee, Hadis [2 ,3 ,4 ]
Eatemadi, Ali [2 ,3 ,4 ]
机构
[1] Lorestan Univ Med Sci, Dept Cardiol, Khorramabad, Iran
[2] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran
[3] Lorestan Univ Med Sci, Sch Med, Dept Med Biotechnol, Lorestan, Iran
[4] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Lorestan, Iran
关键词
Nano-liposomes; Myocardial infarction; Nanoparticles; Atherosclerosis; CONTROLLED CLINICAL-TRIAL; IN-VIVO; BIOMEDICAL APPLICATIONS; GOLD NANOPARTICLES; CONTRAST AGENT; GENE-TRANSFER; DOUBLE-BLIND; ANESTHESIA; MACROPHAGES; NANOSENSORS;
D O I
10.1016/j.biopha.2016.12.009
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Nanoliposomes are type of nano-sized vesicles made of bi-layered phospholipid membranes with an aqueous interior. They have been demonstrated to deliver several materials like low molecular weight drugs, imaging agents, peptides, proteins, and nucleic acids. Nanoliposomes have been demonstrated to slowly release an encapsulated drug, thereby leading to sustained exposure to target region and improved efficacy. This ability of nano-liposomes can be harnessed to deliver therapeutic agents precisely to the infarcted heart. Accordingly, this article will review recent developments in the application of nano liposomes and nanoparticles as drug delivery systems to treat cardiovascular related disorders such as atherosclerosis, restenosis and myocardial infarction. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:316 / 323
页数:8
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