Treatment of peritoneal metastases from colorectal cancer

被引:34
作者
Maerz, Loreen [1 ]
Piso, Pompiliu [1 ]
机构
[1] St John God Hosp Regensburg, Dept Surg, Regensburg, Germany
来源
GASTROENTEROLOGY REPORT | 2015年 / 3卷 / 04期
关键词
colorectal cancer; peritoneal metastases; cytoreductive surgery; intraperitoneal chemotherapy; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; COMPLETE CYTOREDUCTIVE SURGERY; SYSTEMIC CHEMOTHERAPY; HIGH-RISK; 1ST-LINE TREATMENT; REGIONAL TREATMENT; PLUS HIPEC; CARCINOMATOSIS; TRIAL; ORIGIN;
D O I
10.1093/gastro/gov044
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Peritoneal seedings of a colorectal tumor represent the second most frequent site of metastasis (after the liver). In the era of 5-fluorouracil (5-FU)-only chemotherapy, the prognosis was poor for colorectal cancer with peritoneal metastases. Within the last few years, new chemotherapeutic and targeted agents have improved the prognosis; however, the response to these treatments seems to be lower than that for liver metastases. The combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have further improved both disease-free survival and overall survival. Keeping this in mind, every patient presenting with peritoneal metastases from colorectal cancer should be evaluated and receive adequate treatment, if possible in the above-mentioned combination. This paper reviews recent advancements in the therapy of peritoneal carcinomatosis.
引用
收藏
页码:298 / 302
页数:5
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