Bone Regeneration of Rat Tibial Defect by Zinc-Tricalcium Phosphate (Zn-TCP) Synthesized from Porous Foraminifera Carbonate Macrospheres

被引：26

作者：

Chou, Joshua ^{[1
,2
]}

Hao, Jia ^{[3
]}

Kuroda, Shinji ^{[3
]}

Bishop, David ^{[2
]}

Ben-Nissan, Besim ^{[2
]}

Milthorpe, Bruce ^{[2
]}

Otsuka, Makoto ^{[1
]}

机构：

[1] Musashino Univ, Fac Pharm, Pharmaceut Sci Res Inst, 1-1-20 Shin Machi, Nishitokyo, Tokyo 2028585, Japan

[2] Univ Technol Sydney, Fac Sci, Sydney, NSW 2007, Australia

[3] Tokyo Med & Dent Univ, Bunkyo Ku, Tokyo 1138510, Japan

来源：

MARINE DRUGS | 2013年 / 11卷 / 12期

基金：

日本学术振兴会;

关键词：

biomimetic; zinc-tricalcium phosphate; foraminifera; bone defect; bone regeneration; RELEASE; CORAL;

D O I：

10.3390/md11125148

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Foraminifera carbonate exoskeleton was hydrothermally converted to biocompatible and biodegradable zinc-tricalcium phosphate (Zn-TCP) as an alternative biomimetic material for bone fracture repair. Zn-TCP samples implanted in a rat tibial defect model for eight weeks were compared with unfilled defect and beta-tricalcium phosphate showing accelerated bone regeneration compared with the control groups, with statistically significant bone mineral density and bone mineral content growth. CT images of the defect showed restoration of cancellous bone in Zn-TCP and only minimal growth in control group. Histological slices reveal bone in-growth within the pores and porous chamber of the material detailing good bone-material integration with the presence of blood vessels. These results exhibit the future potential of biomimetic Zn-TCP as bone grafts for bone fracture repair.

引用

页码：5148 / 5158

页数：11

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