Platelet-derived growth factor receptors (PDGFRs) fusion genes involvement in hematological malignancies

被引：30
作者：
Appiah-Kubi, Kwaku [1 ,3 ]
Lan, Ting [1 ]
Wang, Ying [1 ]
Qian, Hai [1 ]
Wu, Min [1 ]
Yao, Xiaoyuan [2 ]
Wu, Yan [1 ]
Chen, Yongchang [1 ]
机构：
[1] Jiangsu Univ, Sch Med, Dept Physiol, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China
[2] Changchun Med Coll, Basic Med Dept, Changchun 130013, Jilin, Peoples R China
[3] Univ Dev Studies, Dept Appl Biol, Navrongo, Ghana
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2017年 / 109卷
基金：
中国国家自然科学基金;
关键词：
PDGFRs; Fusion genes; Myeloid neoplasm; Lymphoid neoplasm; Chromosomal translocation; TYROSINE KINASE INHIBITOR; CHRONIC EOSINOPHILIC LEUKEMIA; CHRONIC MYELOPROLIFERATIVE DISORDERS; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOID-LEUKEMIA; FACTOR-ALPHA RECEPTOR; BCR-ABL; CHRONIC-PHASE; MYELOMONOCYTIC LEUKEMIA; FIP1L1-PDGFRA FUSION;
D O I：
10.1016/j.critrevonc.2016.11.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: To investigate oncogenic platelet-derived growth factor receptor(PDGFR) fusion genes involvement in hematological malignancies, the advances in the PDGFR fusion genes diagnosis and development of PDGFR fusions inhibitors. Methods: Literature search was done using terms "PDGFR and Fusion" or "PDGFR and Myeloid neoplasm" or 'PDGFR and Lymphoid neoplasm' or "PDGFR Fusion Diagnosis" or "PDGFR Fusion Targets" in databases including PubMed, ASCO.org, and Medscape. Results: Out of the 36 fusions detected, ETV6(TEL)-PDGFRB and FIP1L1-PDGFRA fusions were frequently detected, 33 are as a result of chromosomal translocation, FIP1L1-PDGFRA and EBF1-PDGFRB are the result of chromosomal deletion and CDK5RAP2- PDGFRA is the result of chromosomal insertion. Seven of the 34 rare fusions have detectable reciprocals. Conclusion: RNA aptamers are promising therapeutic target of PDGFRs and diagnostic tools of PDGFRs fusion genes. Also, PDGFRs have variable prospective therapeutic strategies including small molecules, RNA aptamers, and interference therapeutics as well as development of adaptor protein Lnk mimetic drugs. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：20 / 34
页数：15
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