Novel isocyanide-based three-component reaction: a facile synthesis of substituted 1H-chromeno[2,3-d]pyrimidine-5-carboxamides

被引：32

作者：

Soleimani, Ebrahim ^{[1
,2
]}

Ghorbani, Somayeh ^{[1
]}

Ghasempour, Hamid Reza ^{[2
]}

机构：

[1] Razi Univ, Dept Chem, Kermanshah 6714967346, Iran

[2] Islamic Azad Univ, Sci & Res Branch, Dept Biotechnol & Chem Engn, Kermanshah, Iran

来源：

TETRAHEDRON | 2013年 / 69卷 / 39期

基金：

美国国家科学基金会;

关键词：

Chromeno[2,3-d]pyrimidine; Multicomponent reactions; Benzopyran; Salicylaldehyde; Barbituric acid; Isocyanide; MULTICOMPONENT REACTIONS SYNTHESIS; ORGANIC-SYNTHESIS; CONDENSATION; STRATEGIES; DISCOVERY; CHEMISTRY;

D O I：

10.1016/j.tet.2013.06.080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient method for the synthesis of 1H-chromeno[2,3-d]pyrimidine-5-carboxamide derivatives via a one-pot, three-component reaction of an isocyanide, barbituric acid, and a salicylaldehyde in the presence of acetic acid in ethanol/water mixture at 75 degrees C is reported. This high atom economy reaction led to the construction of one benzopyran ring, and one amide group in a single synthetic step. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：8511 / 8515

页数：5

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