Functional Relapses in Pediatric Multiple Sclerosis

被引：7
作者：
Carbonell, Cristina Fernandez [1 ]
Benson, Leslie [1 ]
Rintell, David [1 ,2 ]
Prince, Jefferson [2 ]
Chitnis, Tanuja [1 ]
机构：
[1] Massachusetts Gen Hosp, Dept Child Neurol, Partners Pediat Multiple Sclerosis Ctr, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Child Psychiat, Boston, MA 02114 USA
来源：
JOURNAL OF CHILD NEUROLOGY | 2014年 / 29卷 / 07期
关键词：
Pediatric multiple sclerosis; functional relapses; children and adolescents; CHRONIC PHYSICAL ILLNESS; PSYCHOGENIC NONEPILEPTIC SEIZURES; CONVERSION DISORDER; ADOLESCENTS; CHILDREN; METAANALYSIS; SYMPTOMS; ONSET; EXACERBATION; ASSOCIATION;
D O I：
10.1177/0883073813501873
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Multiple sclerosis in children is characterized by more frequent relapses than in adult patients. Diagnosing and treating youth with multiple sclerosis present a number of challenges including differentiating organic relapses from functional symptoms. However, there is no literature describing coexistence of functionality in pediatric multiple sclerosis. Here, we report 2 cases in which inconsistency between clinical history, physical examination, imaging, and atypical disease progression led to suspicion of functional relapses. The purpose of this study is to raise awareness of functional relapses, as prompt recognition can prevent overtreatment and iatrogenic risks in children and adolescents with multiple sclerosis. Underlying psychiatric issues also need to be addressed.
引用
收藏
页码：943 / 946
页数：4
相关论文
共 35 条
[1]   Cognitive and psychosocial features in childhood and juvenile MS Two-year follow-up [J].
Amato, M. P. ;
Goretti, B. ;
Ghezzi, A. ;
Lori, S. ;
Zipoli, V. ;
Moiola, L. ;
Falautano, M. ;
De Caro, M. F. ;
Viterbo, R. ;
Patti, F. ;
Vecchio, R. ;
Pozzilli, C. ;
Bianchi, V. ;
Roscio, M. ;
Martinelli, V. ;
Comi, G. ;
Portaccio, E. ;
Trojano, M. .
NEUROLOGY, 2010, 75 (13) :1134-1140
[2]  
Bisht J, 2008, INDIAN PEDIATR, V45, P111
[3]   Relationship between stress and relapse in multiple sclerosis: part II. Direct and indirect relationships [J].
Brown, R. F. ;
Tennant, C. C. ;
Sharrock, M. ;
Hodgkinson, S. ;
Dunn, S. M. ;
Pollard, J. D. .
MULTIPLE SCLEROSIS JOURNAL, 2006, 12 (04) :465-475
[4]   Prospective Examination of Anxiety and Depression Before and During Confirmed and Pseudoexacerbations in Patients With Multiple Sclerosis [J].
Burns, Michelle Nicole ;
Nawacki, Ewa ;
Siddique, Juned ;
Pelletier, Daniel ;
Mohr, David C. .
PSYCHOSOMATIC MEDICINE, 2013, 75 (01) :76-82
[5]   MULTIPLE-SCLEROSIS AND HYSTERIA - LESSONS LEARNED FROM THEIR ASSOCIATION [J].
CAPLAN, LR ;
NADELSON, T .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1980, 243 (23) :2418-2421
[6]   Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States [J].
Chitnis, T. ;
Glanz, B. ;
Jaffin, S. ;
Healy, B. .
MULTIPLE SCLEROSIS, 2009, 15 (05) :627-631
[7]   Fatigue and its relationships with cognitive functioning and depression in paediatric multiple sclerosis [J].
Goretti, B. ;
Portaccio, E. ;
Ghezzi, A. ;
Lori, S. ;
Moiola, L. ;
Falautano, M. ;
Viterbo, R. ;
Patti, F. ;
Vecchio, R. ;
Pozzilli, C. ;
Bianchi, V. ;
Cappiello, S. ;
Comi, G. ;
Trojano, M. ;
Amato, M. P. .
MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (03) :329-334
[8]   Psychosocial issue in children and adolescents with multiple sclerosis [J].
Goretti, B. ;
Ghezzi, A. ;
Portaccio, E. ;
Lori, S. ;
Zipoli, V. ;
Razzolini, L. ;
Moiola, L. ;
Falautano, M. ;
De Caro, M. F. ;
Viterbo, R. ;
Patti, F. ;
Vecchio, R. ;
Pozzilli, C. ;
Bianchi, V. ;
Roscio, M. ;
Comi, G. ;
Trojano, M. ;
Amato, M. P. .
NEUROLOGICAL SCIENCES, 2010, 31 (04) :467-470
[9]  
Gorman MP, 2009, ARCH NEUROL-CHICAGO, V66, P54, DOI 10.1001/archneurol.2008.505
[10]   CLINICAL-FEATURES OF CONVERSION DISORDER [J].
GRATTANSMITH, P ;
FAIRLEY, M ;
PROCOPIS, P .
ARCHIVES OF DISEASE IN CHILDHOOD, 1988, 63 (04) :408-414
1234