Clinical and genetic risk factors for the prediction of hepatotoxicity induced by docetaxel, epirubicin and cyclophosphamide regimen in breast cancer patients

被引：3
作者：
Huang, Shunmin [1 ,2 ]
Yang, Jing [1 ,2 ]
Fu, Fangmeng [3 ]
Wang, Chuan [3 ]
Guo, Xiaoxiong [4 ]
He, Baochang [5 ]
Xiao, Danni [6 ]
Cai, Hongfu [1 ,2 ]
Liu, Maobai [1 ,2 ]
机构：
[1] Fujian Med Univ, Union Hosp, Dept Pharm, Fuzhou 350001, Peoples R China
[2] Fujian Med Univ, Sch Pharm, Fuzhou 350122, Peoples R China
[3] Fujian Med Univ, Union Hosp, Dept Gen Surg, Fuzhou 350001, Peoples R China
[4] Fujian Med Univ, Union Hosp, Dept Gastroenterol, Fuzhou 350001, Peoples R China
[5] Fujian Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Fuzhou 350122, Peoples R China
[6] Fujian Med Univ, Union Hosp, Dept Ultrasound, Fuzhou 350001, Peoples R China
来源：
PHARMACOGENOMICS | 2021年 / 22卷 / 02期
关键词：
combined analysis; early breast cancer; gene polymorphism; risk factors; TEC regimen-induced liver injury; INDUCED LIVER-INJURY; OXIDATIVE STRESS; TOXICITY; POLYMORPHISM; DOXORUBICIN; EXPRESSION; CHEMOTHERAPY; EFFICACY; VARIANTS; PROMOTES;
D O I：
10.2217/pgs-2020-0080
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To screen clinical and genetic risk factors and examine their combined effect on docetaxel, epirubicin and cyclophosphamide (TEC) regimen-induced liver injury (TEC-ILI). Patients & methods: We enrolled 396 breast cancer patients, and TEC-ILI-associated factors were screened by logistic regression analyses. Results: SOD2 rs4880 and ABCG2 rs2231142 polymorphisms correlated with an increased risk of TEC-ILI. Multivariate analysis incorporating clinical and genetic factors revealed that ABCC1 rs246221 (CC) and SOD2 rs4880 (AG/GG) increased the risk of TEC-ILI. Patients with at least two risk factors among nonalcoholic fatty liver disease, high low-density lipoproteinemia levels and the rs246221 or rs4880 adverse genotypes exhibited a significantly increased risk of developing TEC-ILI. Conclusion: The combination of clinical and genetic risk factors had higher predictive value for TEC-ILI than the interclinical risk factors alone.
引用
收藏
页码：87 / 98
页数：12
相关论文
共 50 条
  • [1] Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia
    Alachkar, H.
    Fulton, N.
    Sanford, B.
    Malnassy, G.
    Mutonga, M.
    Larson, R. A.
    Bloomfield, C. D.
    Marcuccis, G.
    Nakamura, Y.
    Stock, W.
    [J]. PHARMACOGENOMICS JOURNAL, 2017, 17 (03) : 274 - 279
  • [2] EASL Clinical Practice Guidelines: Drug-induced liver injury
    Andrade, Raul J.
    Aithal, Guruprasad P.
    Bjornsson, Einar S.
    Kaplowitz, Neil
    Kullak-Ublick, Gerd A.
    Karlsen, Tom H.
    [J]. JOURNAL OF HEPATOLOGY, 2019, 70 (06) : 1222 - 1261
  • [3] Drug-induced liver injury:: An analysis of 461 incidences submitted to the Spanish Registry over a 10-year period
    Andrade, RJ
    Lucena, MI
    Fernández, MC
    Pelaez, G
    Pachkoria, K
    García-Ruiz, E
    García-Munoz, B
    González-Grande, R
    Pizarro, A
    Durán, JA
    Jiménez, M
    Rodrigo, L
    Romero-Gomez, M
    Navarro, JM
    Planas, R
    Costa, J
    Borras, A
    Soler, A
    Salmerón, J
    Martin-Vivaldi, R
    [J]. GASTROENTEROLOGY, 2005, 129 (02) : 512 - 521
  • [4] Bosó V, 2014, PHARMACOGENOMICS, V15, P1845, DOI [10.2217/PGS.14.127, 10.2217/pgs.14.127]
  • [5] Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients
    Cao, Hai-xia
    Miao, Chao-feng
    Yan, Liang
    Tang, Ping
    Zhang, Li-rong
    Sun, Ling
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2017, 15
  • [6] ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
    Chalasani, Naga P.
    Hayashi, Paul H.
    Bonkovsky, Herbert L.
    Navarro, Victor J.
    Lee, William M.
    Fontana, Robert J.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (07) : 950 - 966
  • [7] Indo-Pacific humpback dolphins (Sousa chinensis) in Hong Kong: Modelling demographic parameters with markrecapture techniques
    Chan, Stephen C. Y.
    Karczmarski, Leszek
    [J]. PLOS ONE, 2017, 12 (03):
  • [8] Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes
    Cheung, Kyle G.
    Cole, Laura K.
    Xiang, Bo
    Chen, Keyun
    Ma, Xiuli
    Myal, Yvonne
    Hatch, Grant M.
    Tong, Qiang
    Dolinsky, Vernon W.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (17) : 10981 - 10993
  • [9] Sex Bias in Experimental Immune-Mediated, Drug-Induced Liver Injury in BALB/c Mice: Suggested Roles for Tregs, Estrogen, and IL-6
    Cho, Joonhee
    Kim, Lina
    Li, Zhaoxia
    Rose, Noel R.
    Talor, Monica Vladut
    Njoku, Dolores B.
    [J]. PLOS ONE, 2013, 8 (04):
  • [10] ABCB1 and ABCC1 Variants Associated With Virological Failure of First-Line Protease Inhibitors Antiretroviral Regimens in Northeast Brazil Patients
    Coelho, Antonio V. C.
    Silva, Suedja P. S.
    de Alencar, Luiz C. A.
    Stocco, Gabriele
    Crovella, Sergio
    Brandao, Lucas A. C.
    Guimaraes, Rafael L.
    [J]. JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 53 (12) : 1286 - 1293
12345