Metabolic enzymes: key modulators of functionality in cancer stem-like cells

被引：11
作者：
Dong, Bo-Wen [1 ]
Qin, Guang-Ming [2 ]
Luo, Yan [3 ]
Mao, Jian-Shan [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gastroenterol, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Clin Lab Med, Sch Med, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Basic Med Sci, Hangzhou, Zhejiang, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 08期
基金：
中国国家自然科学基金;
关键词：
cancer stem-like cells; metabolism; enzymes; stemness; mechanism; TUMOR-INITIATING CELLS; PROTEASOME SUBUNIT EXPRESSION; LACTATE-DEHYDROGENASE; SELF-RENEWAL; LUNG-CANCER; GLUTAMINE-METABOLISM; INDUCED APOPTOSIS; SENSITIZES CELLS; PYRUVATE-KINASE; HEXOKINASE II;
D O I：
10.18632/oncotarget.14041
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer Stem-like Cells (CSCs) are a subpopulation of cancer cells with self-renewal capacity and are important for the initiation, progression and recurrence of cancer diseases. The metabolic profile of CSCs is consistent with their stem-like properties. Studies have indicated that enzymes, the main regulators of cellular metabolism, dictate functionalities of CSCs in both catalysis-dependent and catalysis-independent manners. This paper reviews diverse studies of metabolic enzymes, and describes the effects of these enzymes on metabolic adaptation, gene transcription and signal transduction, in CSCs.
引用
收藏
页码：14251 / 14267
页数：17
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