Vitamin D and multiple sclerosis: where do we go from here?

被引：16

作者：

Salzer, Jonatan ^{[1
]}

Bistrom, Martin ^{[1
]}

Sundstrom, Peter ^{[1
]}

机构：

[1] Umea Univ, Dept Pharmacol & Clin Neurosci, Neurol Sect, SE-90187 Umea, Sweden

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2014年 / 14卷 / 01期

关键词：

multiple sclerosis; primary prevention; prospective biobank studies; randomized controlled trials; ultraviolet B (UVB) radiation; vitamin D; RANDOMIZED CONTROLLED-TRIAL; CIS-UROCANIC ACID; PLACEBO-CONTROLLED TRIAL; GENOME-WIDE ASSOCIATION; 25-HYDROXYVITAMIN D; D SUPPLEMENTATION; DOUBLE-BLIND; D DEFICIENCY; HUMAN-SKIN; CARDIOVASCULAR-DISEASE;

D O I：

10.1586/14737175.2014.864952

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This article briefly introduces the basics of multiple sclerosis' (MS) clinical hallmarks and pathophysiology. Vitamin D is presented, including its metabolism and effects on the immune system. The epidemiological observations linking vitamin D to MS range from a half century old findings of latitude gradients and migrational risk patterns to modern, nested, case-control biobank studies. These observations show an association without doubt although causation has yet to be proven. Vitamin D as a treatment for MS is an emerging concept and both current and anticipated data will be covered. Lastly, we discuss future challenges, ideas on how to move from association to causation, and the prospect of primary prevention of this disabling disease.

引用

页码：9 / 18

页数：10

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