Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells

被引：42

作者：

Pereira, Patricia M. R. ^{[1
,2
]}

Carvalho, Jose J. ^{[3
]}

Silva, Sandrina ^{[1
,2
]}

Cavaleiro, Jose A. S. ^{[1
,2
]}

Schneider, Rudolf J. ^{[3
]}

Fernandes, Rosa ^{[4
,5
]}

Tome, Joao P. C. ^{[1
,2
,6
]}

机构：

[1] Univ Aveiro, QOPNA, P-3810193 Aveiro, Portugal

[2] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal

[3] BAM Fed Inst Mat Res & Testing, D-12489 Berlin, Germany

[4] Univ Coimbra, IBILI, P-3000548 Coimbra, Portugal

[5] Univ Coimbra, Fac Med, P-3000548 Coimbra, Portugal

[6] Univ Ghent, Dept Organ Chem, B-9000 Ghent, Belgium

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 11期

关键词：

IN-VITRO; PHOTODYNAMIC THERAPY;

D O I：

10.1039/c3ob42082e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.

引用

页码：1804 / 1811

页数：8

共 27 条

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