Lifelong Persistence of Toxoplasma Cysts: A Questionable Dogma?

被引：55
作者：
Rougier, Solene [1 ]
Montoya, Jose G. [2 ,3 ,4 ]
Peyron, Francois [1 ]
机构：
[1] Hop Croix Rousse, Inst Parasitol & Mycol Med, Hosp Civils Lyon, F-69317 Lyon, France
[2] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Div Infect Dis, Stanford, CA 94305 USA
[4] Palo Alto Med Fdn, Toxoplasma Serol Lab, Palo Alto, CA 94301 USA
来源：
TRENDS IN PARASITOLOGY | 2017年 / 33卷 / 02期
关键词：
IFN-GAMMA PRODUCTION; T-CELL EXHAUSTION; GONDII INFECTION; CONGENITAL TOXOPLASMOSIS; IMMUNE-RESPONSE; INTERFERON-GAMMA; UNITED-STATES; MICE; PREGNANCY; RESISTANCE;
D O I：
10.1016/j.pt.2016.10.007
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
It is believed that infection by Toxoplasma gondii triggers a lifelong protective immunity due to the persistence of parasitic cysts which induce immunoprotection against reinfection. A review of the scientific literature since the 1950s did not yield any definitive data regarding the duration of cysts in the host or the presence of lifelong protective immunity, which led us to question this dogma. We put forward the hypothesis that sustained immunity to T. gondii requires repeated antigenic stimulations. The decline of seroprevalence recently observed in many countries might contribute to explain the loss of immunity. We address the potential consequences of this phenomenon, should it persist and worsen.
引用
收藏
页码：93 / 101
页数：9
相关论文
共 69 条
[21]  
Filisetti Denis, 2004, Ann Ist Super Sanita, V40, P71
[22]  
FRENKEL JK, 1974, B NEW YORK ACAD MED, V50, P182
[23]  
FRENKEL JK, 1973, COCCIDIA EIMERIA ISO
[24]  
GAZZINELLI R, 1992, J IMMUNOL, V149, P175
[25]  
GAZZINELLI RT, 1991, J IMMUNOL, V146, P286
[26]   T cell exhaustion in protozoan disease [J].
Gigley, Jason P. ;
Bhadra, Rajarshi ;
Moretto, Magali M. ;
Khan, Imtiaz A. .
TRENDS IN PARASITOLOGY, 2012, 28 (09) :377-384
[27]  
Halonen Sandra K, 2013, Handb Clin Neurol, V114, P125, DOI 10.1016/B978-0-444-53490-3.00008-X
[28]   Toxoplasmosis: Comparative species susceptibility and host immune response [J].
Innes, EA .
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 1997, 20 (02) :131-138
[29]   TOXOPLASMA AND TOXOPLASMOSIS [J].
JACOBS, L .
ANNUAL REVIEW OF MICROBIOLOGY, 1963, 17 :429-+
[30]   EXPERIMENTAL TOXOPLASMOSIS IN PIGEONS [J].
JACOBS, L ;
MELTON, ML ;
COOK, MK .
EXPERIMENTAL PARASITOLOGY, 1953, 2 (04) :403-416
1234567