Lifelong Persistence of Toxoplasma Cysts: A Questionable Dogma?

被引：55

作者：

Rougier, Solene ^{[1
]}

Montoya, Jose G. ^{[2
,3
,4
]}

Peyron, Francois ^{[1
]}

机构：

[1] Hop Croix Rousse, Inst Parasitol & Mycol Med, Hosp Civils Lyon, F-69317 Lyon, France

[2] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Div Infect Dis, Stanford, CA 94305 USA

[4] Palo Alto Med Fdn, Toxoplasma Serol Lab, Palo Alto, CA 94301 USA

来源：

TRENDS IN PARASITOLOGY | 2017年 / 33卷 / 02期

关键词：

IFN-GAMMA PRODUCTION; T-CELL EXHAUSTION; GONDII INFECTION; CONGENITAL TOXOPLASMOSIS; IMMUNE-RESPONSE; INTERFERON-GAMMA; UNITED-STATES; MICE; PREGNANCY; RESISTANCE;

D O I：

10.1016/j.pt.2016.10.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

It is believed that infection by Toxoplasma gondii triggers a lifelong protective immunity due to the persistence of parasitic cysts which induce immunoprotection against reinfection. A review of the scientific literature since the 1950s did not yield any definitive data regarding the duration of cysts in the host or the presence of lifelong protective immunity, which led us to question this dogma. We put forward the hypothesis that sustained immunity to T. gondii requires repeated antigenic stimulations. The decline of seroprevalence recently observed in many countries might contribute to explain the loss of immunity. We address the potential consequences of this phenomenon, should it persist and worsen.

引用

页码：93 / 101

页数：9

共 69 条

[1]

Ancelle T., 1996, Bulletin Epidemiologique Hebdomadaire, P227

[2]

Berger F., 2008, Bull Epidemiol Hebd, V14, P117

[3] TOXOPLASMOSIS [J].

BEVERLEY, JK .

BRITISH MEDICAL JOURNAL, 1973, 2 (5864) :475-478

[4] Genetic characterization of Toxoplasma gondii isolates from pigs intended for human consumption in Brazil [J].

Bezerra, R. A. ;

Carvalho, F. S. ;

Guimaraes, L. A. ;

Rocha, D. S. ;

Maciel, B. M. ;

Wenceslau, A. A. ;

Lopes, C. W. G. ;

Albuquerque, G. R. .

VETERINARY PARASITOLOGY, 2012, 189 (2-4) :153-161

[5] Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade [J].

Bhadra, Rajarshi ;

Gigley, Jason P. ;

Weiss, Louis M. ;

Khan, Imtiaz A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (22) :9196-9201

[6] Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection [J].

Bliss, SK ;

Butcher, BA ;

Denkers, EY .

JOURNAL OF IMMUNOLOGY, 2000, 165 (08) :4515-4521

[7] Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions? [J].

Butler, Noah S. ;

Harris, Tajie H. ;

Blader, Ira J. .

TRENDS IN PARASITOLOGY, 2013, 29 (12) :593-602

[8] The gut mucosal immune response to Toxoplasma gondii [J].

Cohen, S. B. ;

Denkers, E. Y. .

PARASITE IMMUNOLOGY, 2015, 37 (03) :108-117

[9] Relevance of and New Developments in Serology for Toxoplasmosis [J].

Dard, Celine ;

Fricker-Hidalgo, Helene ;

Brenier-Pinchart, Marie-Pierre ;

Pelloux, Herve .

TRENDS IN PARASITOLOGY, 2016, 32 (06) :492-506

[10] Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection [J].

Denkers, EY ;

Gazzinelli, RT .

CLINICAL MICROBIOLOGY REVIEWS, 1998, 11 (04) :569-+

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