Sequelae of chorioamnionitis

被引:114
作者
Hagberg, H [1 ]
Wennerholm, UB [1 ]
Sävman, K [1 ]
机构
[1] Sahlgrenska Univ Hosp E, Ins Hlth Women & Children, Dept Obstet & Gynecol, Perinatal Ctr, S-41685 Gothenburg, Sweden
关键词
D O I
10.1097/00001432-200206000-00014
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Chorioamnionitis correlates to preterm delivery prior to 30 weeks of gestation. In most studies, proxies of intrauterine infection (clinical chorioamnionitis, histological chorioamnionitis, intra-amniotic increase in cytokines) are associated with acute neonatal morbidity and mortality and, at least to some degree, with neurological impairments (periventricular leukomalacia, intraventricular hemorrhage, cerebral palsy, polymicrogyria), chronic lung disease, and involution of the thymus in the preterm infant. The connection to visual impairment and cognitive deficits is uncertain or unknown. Full-term babies exposed to intrauterine infection often present with depressed Apgar scores and neonatal encephalopathy, and are at markedly increased risk of developing cerebral palsy. The infectious/ inflammatory mechanisms involved are incompletely understood, and the types of microbes, as well as the genetic characteristics of the host adaptive and innate immune response, need to be better characterized.
引用
收藏
页码:301 / 306
页数:6
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