Frustrated Lewis Pair Catalyzed Hydroamination of Terminal Alkynes

被引：105

作者：

Mahdi, Tayseer ^{[1
]}

Stephan, Douglas W. ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 47期

基金：

加拿大自然科学与工程研究理事会;

关键词：

alkynes; enamines; frustrated Lewis pairs; hydroamination; hydrogenation; INTERMOLECULAR HYDROAMINATION; COPE-TYPE; HYDROGENATION; ACTIVATION; MECHANISM; DERIVATIVES; REACTIVITY; COMPLEXES; ENAMINES; ALKENES;

D O I：

10.1002/anie.201307254

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic amounts of the Lewis acid B(C6F5) 3 enable the hydroamination of terminal alkynes by aryl amines to the corresponding enamines. In accord with the results of stoichiometric reactions, the mechanism of this reaction involves a frustrated Lewis pair (FLP). The hydroamination can be followed by an FLP-catalyzed hydrogenation, resulting in a one-pot stepwise synthesis of amine derivatives. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12418 / 12421

页数：4

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