Carbon nanotubes as vaccine scaffolds

被引：53
作者：
Scheinberg, David A. [1 ]
McDevitt, Michael R.
Dao, Tao
Mulvey, J. Justin
Feinberg, Evan
Alidori, Simone
机构：
[1] Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, Dept Med, New York, NY 10021 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2013年 / 65卷 / 15期
关键词：
Carbon nanotubes; vaccines; adjuvants; antigen presenting cells; LARGE-SCALE PURIFICATION; T-CELL RESPONSES; CANCER VACCINES; DENDRITIC CELLS; SIDEWALL FUNCTIONALIZATION; IMMUNOLOGICAL ADJUVANTS; DELIVERY-SYSTEMS; GM-CSF; PEPTIDE; IMMUNOTHERAPY;
D O I：
10.1016/j.addr.2013.07.013
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Carbon nanotubes display characteristics that are potentially useful in their development as scaffolds for vaccine compositions. These features include stability in,vivo, lack of intrinsic immunogenicity, low toxicity, and the ability to be appended with multiple copies of antigens. In addition, the particulate nature of carbon nanotubes and their unusual properties of rapid entry into antigen-presenting cells, such as dendritic cells, make them especially useful as carriers of antigens. Early attempts demonstrating carbon nanotube-based vaccines can be used in both infectious disease settings and cancer are promising. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：2016 / 2022
页数：7
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